Recently, COVID-19 caused mainly by the fast-spreading as compared with primary infections of new variant 'Omicron-SARS-CoV-2, the blind-spots, may have killed nearly 3 million only in India, and the whole world, opening a new chapter that has impacted our lives, and the highest number of Covid-19 deaths due to lack of vaccines gasping for air now. So, it is urgently needed the ‘Universal-Preventive-Emergency-Vaccine for All’ to tackle the awkward situation. Primarily, it has been already observed that the Ginger-MT-biomedicines, prepared from the rhizome of ginger (Zingiber officinale Rosc.), at an extremely-ultra-low-doses, highly effective against coronavirus controlling-COVID-19, and other diseases by increasing natural immunity. Now the aims and objective of the present ‘Notable-Case-Reports (NCR)’ are to see, record, and confirm the efficacy of the ‘High-Diluted-Traditional-Ginger-MT-Biomedicines (HDTGMTBM)’, against naturally occurring coronavirus infections or re-infections of the different-COVID-19-areas of the Burdwan-Municipality, Purba Bardhaman, West Bengal, India. And to highlight novel and significant future aspects of the study with the ‘Black Ginger’, the rhizome of Kaempferia parviflora. As a result in the ‘New-Year-2022; “‘Traditional-And-Black-Ginger-Biomedicines (TABGBM)’ May Be Act As ‘Notable-Universal-Preventive-Emergenc

Vaccine (NUPEV)’ Against 'Future-A to Z-Diseases (FAZD)’ Enriched ‘Clinical-Case-Reports-Medical-Science-Technology-Communication-Research-Innovation-Global-Health-Ecology-Application (CCRMSTCRIGHEA)”. And in near future, both the Ginger MT-Biomedicines may easily tackle many diseases and complications. I will be ‘NUPEV’ due to medicines formulations, very-low-toxicity, potential efficacy, and different phytochemicals, eco-friendly-side-effects-free, cost-effective, easily prepare-able, easily available, easily-manufacture-able, easily-equitable, easily-marketable and easily-supply-able, etc. And in the future, it will be ‘Policy Initiative Potentially Life-Saving 'Future-A to Z-Vaccine for All’.

The COVID-19 disease caused by the infection or recinfection of the recent fast-spreading-'Omicron-SARS-CoV-2, the blind-spots, may have killed nearly 3 million only in India, and the whole world, first-time passed one-million per day on an average opening new-chapter in the COVID-19-pandemic, difficult to tackle and tract, and has badly impacted our social lives, education, socioeconomic, etc., and nearly each and every corner of the world, and the highest number of total 850,000 Covid-19 deaths have been reported in the United States, and the rest of the globe have been more than 5.4 million deaths due to lack of vaccines (Figure 1) and we are gasping for air, and this 'Omicron-SARS-CoV-2-wave is different from the previous one, and hot spots from New York to Florida to Texas, generally no need to admit in the intensive care units or ventilation or hospitalized (15%), compared with Delta patients 43 % and 55% Alpha patients, and in India’s major cities are experiencing nearly 50%  or more, 90% in Delhi, increases in cases overnight Omicron attack , just a few months after the deadly Delta attack, and the 15,000 cases in Mumbai reported, and the World Health Organization said that the  Omicron is peaking, and more than half of those in Europe could be infected with Omicron in the next six to eight weeks [1-6]. Now the “Universal-Coronavirus-Vaccines OR the Booster-Vaccine” may be solved the recent crisis [7, 8]. It has been already observed that the biomedicines-Zingiber officinale Rosc. At an extremely ultra-low-dose, prepared from the rhizome of ginger, a promising drug of choice for COVID-19 by increasing natural immunity [9-13]. Still, now, the vaccines were also not equally available globally, as the majority of them were distributed in middle- and high-income countries. So, in the ‘New Year 2022’ preventing shortfalls that impact a global crisis on sustainable development, it has been tried that the global vaccine will be more equitable clinically important ‘Notable-Clinical-Research-Notes’ preventing the bad-wave ‘Omicron’ [14-16]. It is also noted that ginger is a rich source of different bioactive compounds controlling different diseases due to the presence of effective immunity-boosters; antiviral activity against SARS-CoV-2, Influenza virus, Herpes simplex virus, Human respiratory syncytial virus, and hepatitis C virus, etc. [17]. 

The aims and objectives of present studies are to find out or record randomly different clinical cases to see, observe, highlight, and confirm the efficacy as-‘Notable-Clinical-Research-Notes’ with the treatment Ginger MT-biomedicines, prepared from the rhizome (Plate 1) of traditional common ginger (Zingiber officinale Rosc.), at extremely low doses, in the different COVID-19- treatments areas; individual, family, and different community, etc. of the Burdwan Municipality, Purba Bardhaman District, West Bengal, India. And it will be highlighted novel and significant ideas for the future aspects of the study with the ‘Black Ginger’, the rhizome of Kaempferia parviflora, forming the ‘Notable-Universal-Preventive-Emergency-Vaccine (NUPEV)’ Against 'Future-A to Z-Diseases (FAZD)’ in the ‘New Year 2022’ distributing equally, and preventing shortfalls and global crisis, and oath ourselves “Vaccine equity: there is no time to waste” [18].

Preparation of High-Diluted Biomedicines Powder 

The high-diluted Ginger MT-Biomedicine (HDGMTBM) was prepared from air-dried powdered (Plate 1) of the ginger rhizomes; Zingiber officinale Rosc., extracting with 90% ethanol, forming residue or high-diluted Ginger MT Biomedicine powder (HDGMTBMP), and the high-diluted-Black-Ginger MT Biomedicine powder (HDBGMTBMP) may be prepared from the rhizomes of Kaempferia parviflora, following same procedure after getting permission from the concerned authority if applicable [9-12, 17, 19-21]. 

Preparation of High-Diluted Biomedicines MT

The high-diluted Ginger MT-Biomedicine (HDGMTBM) was prepared from air-dried powdered rhizomes (Plate 1) of the ginger rhizomes; Zingiber officinale Rosc., extracting with 90% ethanol,  forming residue which was diluted in 90% ethanol at 1mg/ml concentration, and the high-diluted-Black-Ginger MT-Biomedicine (HDBGMTBM) may be prepared from the rhizomes of Kaempferia parviflora, following same procedure after getting permission from the concerned authority if applicable  [9-12,17,19-21]. 

Preparation of Ultra-High-Diluted Biomedicines-Liquid (UHDBML) 

The ultra-high-diluted Ginger-Biomedicines-Liquids (UHDGBML); Ginger 30C, Ginger 200C, and Ginger 1000C, were prepared from a few drops of a liquid potency of Ginger 30C, Ginger 200C, and Ginger 1000C, and ultra-high-diluted Black-Ginger-Biomedicines-Liquids (UHDBGBML); maybe prepared Black-Ginger 30C, Black-Ginger 200C, and Black-Ginger 1000C, following same procedure after getting permission from the concerned authority if applicable [9-12,17,19-21]. 

Preparation of Ultra-High-Diluted Biomedicines-Globules (UHDBMG) 

The ultra-high-diluted Ginger-Biomedicines-Globules (UHDGBMG); Ginger 30C, Ginger 200C, and Ginger 1000C, were prepared by soaking the few drops of a liquid potency in the proportion of 7.2 mg globules/ml of Ginger 30C, Ginger 200C, and Ginger 1000C, and following same procedure ultra-high-diluted Black-Ginger-Biomedicines-Globules (UHDBGBMG); Black-Ginger 30C, Black-Ginger 200C, and Black-Ginger 1000C were prepared [9-12,17,19-21]. 

Samples 

The samples were the different individual members, family members, and community members as samples of COVID-19 patients of the containment zones or infected zone or reinfected zones of the Burdwan Municipality as well as Purba Bardhaman District [9-12, 15-54].

Treatments Sample Groups and Duration 

The treated samples were the general patients of the (I)-‘Burdwan Medical College and Hospital (BMCH), coming from different areas of Purba Bardhaman District and the outsider of adjacent District as well as another state also, different COVID-19-patients of (II)-‘Containment Areas’ (CA) of Purba Bardhaman District,  students, parents/guardians, and family members of (III)-‘Kanchannagar D.N. Das High School (HS)’ (KDNDHS), Kanchannagar, Burdwan Municipality, Purba Bardhaman, West Bengal, India from the onset of COVID-19, March 2020 to the end of fast-spreading of COVID-19, December 2021 [9-12,17,19-21]. 

Assistance of Treatments 

Under the instruction of the Hon’ble District Magistrate of Purba Bardhaman, and under the assistance of the Hon’ble Chief Medical Officer, Burdwan Medical College and Hospital and (BMCH AND CMOH) providing the rapid antigen kits for the COVID-19 infected and comorbid patients, the treatments and visits were done at random in the different sample areas  by the Hon’ble treating doctors of ; Dr. Dipanwita Malick, MBBS, and eminent Senior Consultant Physician, Dr. Ranjan Mukherjee, M.B.B.S., M.D., District Coordinator of Sishu Sathi Scheme at Department of Health and Family Welfare, Purba Bardhaman, Burdwan-713102, West Bengal, India, and the Hon’ble special guest doctor, eminent Senior Consultant Physician & Cardiologist Dr. Tushar Kanti Batabyal, M.B.B.S., M.D., Ex-Clinical Tutor of the Burdwan Medical College & Hospital, Government of West Bengal, India, with the help of; the Hon’ble Secretary, Mr. Rakesh Khan, M.A., B.Ed., (Gold Medalist), and the Hon’ble President, Mr. Subhendu Bose, with all Young Green-Members of the ―International NGO named Burdwan Green Haunter and Students‘ Goal,  the secondary- and higher secondary-students, and the energetic community volunteer. The whole schedule was guided and led by Dr. Subhas Chandra Datta, Headmaster, Secretary, Coordinator, and Researcher of Kanchannagar D.N.Das High School (HS), and the treatment was randomized by using a completely randomized block design and guidance, and the rest of the general sample 100%-communities of Purba Bardhaman District, were treated as ‘Control Treatments Groups (01year to 99 years)’ [9-12], and all the information was counted for statistical analysis by the analysis of variance ‘ANOVA’ (P<0>

General Symptoms 

The observation of main symptoms is fever, cough, tiredness, loss of taste or smell, sore throat, headache, aches, and pains, diarrhea, a rash on the skin, or discoloration of fingers or toes, red or irritated eyes, etc. [9-12,17,19-21]. All the information was counted for statistical analysis by the analysis of variance ‘ANOVA’ (P<0>

Doses of Treatments

The treatments were done @ 10-20 drops of the high-diluted-biomedicine Ginger MT (HDBMGMT), is mixed @ 50ml-100ml (a half to a full cup) of moderately hot sterile-distilled-or pure-drinking-water or tea or milk, orally administered @ 5-8 times/day at an interval of 1- 2hrs, after taking any kinds of nutritious biomedicine-enriched-food against naturally occurring coronavirus infections or re-infections, 45-60 days before symptom onset OR illness onset (as a vaccine) OR onset of symptoms where patients in hospital-associated COVID-19 infections have been reported (treatments), and the dose may be increased depending on the intensity of diseases in case of treatment advised by doctors [9-12,17,19-21]. All the information was counted for statistical analysis by the analysis of variance ‘ANOVA’ (P<0>

Types of Treatments

Four types of treatments; oral, nasal, and vaporized, were followed or applied with HDBMGMT –Soaked-N95-Mask for the ‘Notable-Clinical-Research’ [9-12, 17, 19-21]. 

Oral treatments; were done @ 10-20 drops-HDBMGMT/50ml-100ml (a half to a full cup) drinking-water@ 5-8 times/day at an interval of 1- 2hrs.

Nasal treatments; were collected from ‘oral treatment solution’ and were done @ 1-2 drops-HDBMGMT/nostril@ 5-8 times/day at an interval of 1- 2hrs.

Vaporized treatments; were done @ 10-20 drops-HDBMGMT/100ml-200ml (1-2 full cup) hot-pure-water@ 5-8 times-inhalation/day at an interval of 1- 2hrs.

Medicines-Soaked-N95-Mask; were prepared @ 10-20 drops-HDBMGMT/50ml-100ml pure-water soaked@5-10 mask.

 Data Collection and Records Maintenance

All the data was collected from; the treating doctor, individual, NGO, students, and the different webpage [9-12, 17, 19-21]. The higher secondary (H.S.) students collected data from the communities treatments groups maintaining records of the data for statistical analysis by the analysis of variance ‘ANOVA’ (P<0>

Science Technology Communication Applications (STCA)

The NGO-Burdwan Green Haunter and Students‘Goal with the different communities, scholars, researchers, artists, teachers, staff, community, photographers, different scientists, academicians, clinicians, administrators, institutions, farmers, and media personnel, visited making the news and published in different medical journals [9-12, 17, 19-21].

Protocols 

The school students, NGOs, and different young volunteers organized many social-awareness virtual camps (VC) among the communities in different ways; using masks mandate, cleaning hands with soap, maintaining physical distance, and avoiding touching eyes-nose-mouth, etc. [9-12,17,19-21].

Notable-Clinical-Research-Notes

All the important notes were collected by Dr. Subhas Chandra Datta from the Hon’ble treating doctors of; Dr. Dipanwita Malick, MBBS, and eminent Senior Consultant Physician, Dr. Ranjan Mukherjee, M.B.B.S., M.D., District Coordinator of Sishu Sathi Scheme at Department of Health and Family Welfare, Purba Bardhaman, Burdwan-713102, West Bengal, India, and all the data were also try to clarify by Dr. Subhas Chandra Datta [9-12, 17, 19-21].

Table 1 showed the clinical research notes of high-diluted-biomedicines-Ginger MT as preventive as well as treated biomedicines on family and community against COVID-19 or reinfection;  I-Notable-Clinical-Research- Treatments-Notes-Groups, II-Notable-Clinical-Research-Treatments-Notes-Groups, and III-Nota0ble-Clinical-Research- Treatments-Notes-Groups i.e. average treatment/control age groups (01-99 years) of the different family and communities treatment group’s family members regarding the infection or reinfection of coronavirus 2 / omicron of the families in the community of Burdwan Municipality, Bardhaman-I, and Bardhaman –II, Purba Bardhaman, from March 2020 to December 2021, and all the data were significant difference by the analysis of variance ‘ANOVA’ (P<0>

Figure 1: Covid -19 report of Purba Bardhaman and United States (from Web Pages)

 Potential absolute immunization occurred in all ‘Notable-Clinical-Research- Treatments-Notes-Groups’ due to effective-HDBMGMT and natural immunity. It is noted that the COVID-19 was affected different people in different ways. Most infected people would be developed asymptomatic (57%) or mild to moderate illnesses (21%) and would be recovered 94% without hospitalization (Table 1).

  And in the rest of the general 100%  average control age groups (01-99 years) of the different family and communities group’s family members of Purba Bardhaman District, showed the 92.98% to 93.53% -recovery after hospitalization in comparison with the preventive-HDBMGMT- treatment group within the stipulated time, and all were also counted for statistical analysis by the analysis of variance ‘ANOVA’, where 6.47%  to 7.02% died in aged-and-comorbid, heart-and –diabetic, and COVID 19 patient with asymptomatic or mild to moderate illness and recovered after hospitalization within the same period from March 2020 to December 2021, where the most common symptoms were: fever, cough, tiredness, loss of taste or smell, and the less common symptoms were: sore throat, headache, aches, and pains, diarrhea, a rash on the skin, or discoloration of fingers or toes, red or irritated eyes, following the Covid -19 status of Purba Bardhaman District and United States (Figure 1: from Web Pages). It is interesting that the last Covid-wave is the fastest transmissible and infective but less detrimental in all respect in both preventive-HDBMGMT- treatment/control groups (Table 1).

a,b,c’- different small letters in a column, and ‘x,y,z’ different small letters in a row show significant  difference by the analysis of variance ‘ANOVA’ (P<0>

Table 1: 

Clinical research notes of high-diluted-biomédcines-Ginger MT on different community against COVID19

All the treatments groups of all the age groups on family and community against COVID-19 showed the absolute recovery only in-home quarantine due to treatment with the preventive–HDBMGMT (‘high-diluted-biomedicines-Ginger MT’) on family and community against COVID-19 which contains many active effective phytoconstituents or bioactive compounds, and it provides booster immunity or hard immunity or innate immunity preventing also many diseases; analgesic, diuretic, antifungal, vermifuge, antiulcer, laxative, antiviral, asthma, ulcers, diarrhea, swelling of the mouth or throat, and high cholesterol and hypertension, hepatoprotective and antioxidant activities. For these reasons, all the treatment treatments age groups, 1year to 99 years’ showed more than 96% -absolute recovery only in-home isolation or home quarantines were active or passive infection or reinfection occurred after preventive-–HDBMGMT. And it may develop the blueprint with the help of ‘Students-NGO-Model etc., for potential diagnostics, booster vaccines, and therapeutics against novel coronavirus-2 or omicron or future A to Z disease [9-12, 22-61].

It was remarkable that the highest passive infection/reinfection due to the potential effects of preventive–HDBMGMT. So the potential very old traditional cost-effective side-effect-free environment-friendly easily prepare-able easily-manufacture-able equitable-marketable easily-available and supply-able, the best quality-nanoparticles-biomedical–HDBMGMT at extremely low doses, “From Vaccine-Nationalism-to-Vaccine-Equity— Finding a Path-Forward”, and it will resist COVID vaccine hesitancy against new variants, the ‘Omicron’ that has long been recognized as a problem in high- and middle-income nations of the world’s poorest countries, lack of access to vaccines [62]. And the Ginger MT-biomedicines will be ‘Universal Future Diseases Model’ like “Only wildlife conservation may be future omicron-like-preventive-epidemic-covid-19-model enriched forestry- horticulture-agriculture-environment-health-biodiversity science-technology-communication-application-issues” [63].

So, it confirms the efficacy as-‘Notable-Clinical-Research-Notes’ with the treatment Ginger MT-biomedicines, prepared from the rhizome (Plate 1) of traditional common ginger (Zingiber officinale Rosc.), at extremely low doses, in the different COVID-19- treatments areas; individual, family, and different community, etc. of the Burdwan Municipality, Purba Bardhaman District, West Bengal, India. And it is highlighted novel and significant ideas for the future aspects of the study with the ‘Black Ginger’, the rhizome of Kaempferia parviflora, forming the ‘Notable-Universal-Preventive-Emergency-Vaccine (NUPEV)’ Against 'Future-A to Z-Diseases (FAZD)’ in the ‘New Year 2022’ distributing equally, and preventing shortfalls and global crisis, and oath ourselves “Vaccine equity: there is no time to waste” [18]. 

The ‘Traditional-And-Black-Ginger-Biomedicines (TABGBM)’ May Be Act as ‘Notable-Universal-Preventive-Emergency-Vaccine (NUPEV)’ Against 'Future-A to Z-Diseases (FAZD)’ Enriched ‘Clinical-Case-Reports-Medical-Science-Technology-Communication-Research-Innovation-Global-Health-Ecology-Application (CCRMSTCRIGHEA)”. And in near future, both the Ginger MT-Biomedicines may easily tackle many diseases and complications. I will be ‘NUPEV’ due to medicines formulations, very-low-toxicity, potential efficacy, and different phytochemicals, eco-friendly-side-effects-free, cost-effective, easily prepare-able, easily available, easily-manufacture-able, easily-equitable, easily-marketable and easily-supply-able, etc. And in the future, it will be ‘Policy Initiative Potentially Life-Saving 'Future-A to Z-Vaccine for All’. And in the ‘New Year 2022’ distributing equally, and preventing shortfalls and global crisis, and oath ourselves “Vaccine equity: there is no time to waste”.

The authors declare no conflicts of interest here and the manuscripts is written by the author itself.

I am thankful to the eminent educationist Sri Tapaprakash Bhattacharya for inspiration and guidance. I express my deep gratitude to Mr. Rakesh Khan, M.A., B.Ed., (Gold Medalist), Secretary and Mr. Subhendu Bose, President with all Young Green-Members of the ―International NGO named Burdwan Green Haunter and Students‘ Goal‖ for arranging several awareness programmed on COVID-19 with ―Health Care, Biomedicines, Nutritious Food, Vaccination, Agriculture, Biodiversity Conservation and Enriching Science and Technology Communication Economy Application Issues‖. Last but not the least; I am thankful to the eminent Senior Consultant Physician, Dr. Ranjan Mukherjee, M.B.B.S., M.D., District Coordinator, and Dr. Dipanitwa Malik, M.B.B.S. of Sishu Sathi Scheme at Department of Health and Family Welfare, India for inspiration and guidance.