Advanced Wound Management in Suprapubic Pyoderma Gangrenosum Following Cesarean Section: A Strategic Therapeutic Approach

Case Report | DOI: https://doi.org/10.31579/2690-4861/896

Advanced Wound Management in Suprapubic Pyoderma Gangrenosum Following Cesarean Section: A Strategic Therapeutic Approach

  • Eugenia París Coronado *

Physical therapist, general practitioner, and Master's degree in advanced ulcer and wound management. Director of CIP CIMA, San José, Costa Rica.

*Corresponding Author: Eugenia París Coronado, physical therapist, general practitioner, and Master's Degree in Advanced Ulcer and Wound Management. Director of CIP CIMA, San José, Costa Rica.

Citation: Eugenia P. Coronado, (2025), Advanced Wound Management in Suprapubic Pyoderma Gangrenosum Following Cesarean Section: A Strategic Therapeutic Approach, International Journal of Clinical Case Reports and Reviews, 29(4); DOI:10.31579/2690-4861/896

Copyright: © 2025, Eugenia París Coronado. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 23 June 2025 | Accepted: 04 August 2025 | Published: 11 September 2025

Keywords: pyoderma gangrenosum; skin condition; advanced wound management; surgical wound; magnetotherapy

Abstract

Pyoderma gangrenosum (PG) is a rare, painful skin condition characterized by rapidly progressing necrotic ulcers. Due to its complexity, it requires advanced wound management involving thorough assessment, multidisciplinary care, and appropriate use of wound care technology. This case report presents a patient who developed suprapubic PG as a postoperative complication following cesarean delivery. Specialized treatment was administered at the Wound Care Clinic (CH), including the application of antiseptic and bioactive topical agents, a range of advanced dressings -such as nonadherent films, antimicrobial-coated materials, silver-based hydrogels, and collagen matrices-, and the use of adjunctive therapies like magnetotherapy. A structured wound care strategy was implemented, emphasizing decontamination, protection, and the facilitation of tissue regeneration. The intervention resulted in complete reepithelialization and progressive surgical wound closure without further complications. This case underscores the value of advanced wound care protocols in managing complex presentations of PG and highlights the importance of tailored, multidisciplinary approaches in achieving favorable clinical outcomes.

Introduction

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis of uncertain etiology, clinically characterized by painful, rapidly progressive necrotic ulcers with irregular borders. Current evidence points to the overproduction of proinflammatory cytokines -such as Th1, TNF-α, IL-6, and IL-8- as contributors to sterile inflammation driven by neutrophil chemotaxis [1-4]. PG may present at any age, with a reported prevalence of approximately 5.8 cases per 100,000 adults in the United States [5]. Although its pathogenesis remains incompletely understood, immune dysregulation is widely considered a central mechanism [1]. Clinically, PG is classified into six variants: ulcerative (the most prevalent), pustular, bullous, vegetative, peristomal, and postoperative [1,2]. Lesions are typically located on the lower extremities, buttocks, abdominal region, and face, and often manifest as painful necrotic ulcers with potential for permanent scarring [4-6].

Due to its complexity, PG necessitates a comprehensive and specialized wound management strategy [2]. This includes a detailed assessment of the wound’s microenvironment -encompassing molecular, infectious, and genetic factors-alongside coordinated multidisciplinary care and the integration of advanced wound care technologies [7]. The healing process follows a sequence of cellular and molecular events, beginning with vasoconstriction and coagulation and progressing toward tissue regeneration [8]. A thorough patient evaluation should incorporate medical history, laboratory testing, imaging studies, and nutritional assessment. In parallel, wound evaluation must address key parameters such as size, depth, exudate volume and characteristics, condition of surrounding skin, signs of infection, and pain severity [7].

Following a comprehensive evaluation, individualized treatment goals and plans are established -encompassing wound cleansing frequency, appropriate dressing selection, and the use of technologies designed to sustain a moist healing environment and prevent reinfection [2, 7, 8]. One such adjunctive modality is magnetotherapy, which involves the therapeutic application of electromagnetic fields. Since the 19th century, studies have explored the biological effects of magnetic fields on living systems. Magnetotherapy promotes cellular regeneration and collagen formation by restoring membrane potential and correcting ion imbalances within injured tissues [9,10]. As a complementary approach, magnetotherapy may improve wound healing outcomes when integrated with conventional pharmacological interventions [9]. 

Optimal dressing selection plays a pivotal role in wound management. Contemporary dressings are designed to maintain a moist environment, prevent infection, facilitate gaseous exchange, and modulate local inflammatory responses through cytokine regulation. Essential attributes include biocompatibility and non-toxicity to ensure safe application across diverse wound types [8]. Among available options, collagen-based dressings are extensively utilized due to their regenerative capacity and compatibility with native tissue. Collagen promotes fibroblast and keratinocyte function, enhances the synthesis of extracellular matrix proteins, and supports tissue remodeling—rendering it particularly effective in the management of epithelial wounds [7, 8, 11, 12].

The primary aim of this case report is to demonstrate the effectiveness of advanced wound management strategies—including the use of specialized dressings and complementary therapies like magnetotherapy—in promoting healing and achieving full epithelialization in a complex case of suprapubic pyoderma gangrenosum (PG) following a cesarean section. By detailing an interdisciplinary, personalized treatment approach, the article contributes valuable insights into clinical practices for managing rare and challenging postoperative skin conditions.

Case Presentation

A 34-year-old female patient, previously healthy and nulliparous, experienced an uncomplicated pregnancy and underwent a cesarean section on November 28, 2022. The procedure was uneventful, and she was discharged 24 hours postoperatively.  Three days later, on December 1, she reported the onset of fever and general malaise. By December 3, wound dehiscence had developed, measuring approximately 2 cm in length and presenting with a brownish discoloration. On December 4, 2022, the wound exhibited a marked change in coloration, appearing violet, along with increased extension compared to the previous day. The patient reported a fever reaching 39 °C, abdominal pain, jaundice, and a foul odor emanating from the wound site (Figure. 1). 

Figure 1: Increased dehiscence of the wound, with color change (violet), jaundice, and foul odor. Source: Dr. Rauff, 2022.

Following an evaluation by her attending gynecologist, a referral was made for interdisciplinary management involving specialists in Infectious Diseases, Dermatology, and Intensive Care. That same day, the patient underwent surgical debridement of the affected area (Fig. 2), after which the wound was closed surgically.

Figure 2: Surgical cleaning of the wound. Source: Dr. Rauff, 2022.

By December 11, 2022 -one week after surgical closure- partial wound edge separation was observed (Figure. 3). Based on clinical presentation and histopathological findings from biopsies of suprapubic tissue, Dermatology confirmed a diagnosis of pyoderma gangrenosum. The patient was referred to the Wound Care Clinic (CH) for specialized evaluation and advanced wound management. Systemic corticosteroid therapy was initiated. Dermatology further emphasized the importance of gentle wound care and advised the use of non-irritating topical products to minimize trauma and support healing. During the CH’s initial assessment, poorly defined lesions were identified, measuring approximately 4 cm on the right and 3 cm on the left, with abundant yellowish serous exudate. The right side was sutured by Plastic Surgery, while the left was left open in accordance with Dermatology’s guidance to continue conservative, specialized care under CH supervision.

Figure 3: Initial separation of the edges of the surgical wound in the patient. Source: Own, 2022.The initial treatment selected by the CH involved cleansing the wound with a sodium hypochlorite solution for five minutes, followed by the application of a biological dressing designed to promote microbial binding. Four hours later, the patient reported excessive exudate and intolerance to the dressing. The wound was cleansed again with the same antiseptic solution, and an antimicrobial silver-based dressing -formulated to absorb excess fluid and maintain a moist healing environment- was applied, with dressing changes scheduled every 24 hours. On December 13, 2022, the patient presented with dehiscence of the wound's left margin, measuring approximately 7 cm, accompanied by abundant exudate and erythematous peri-wound tissue (Figure. 4).

Figure 4: Separation of the left edge of the wound, with an extension of 7 cm, abundant exudate, and edges surrounded by reddish coloration. Source: Own, 2022.

The clinical team continued treatment using a silver-based antimicrobial dressing as the primary layer, secured with an adhesive bandage. To support wound stability and reduce tension in the abdominal area, a binder was added to the therapeutic approach (Figure. 5).

Figure 5: An abdominal binder was added to the treatment. Source: Own, 2022.

By December 17, 2022, additional dehiscence was noted along the left edge of the wound, measuring approximately 4 cm by 1 cm, characterized by a pearly gray base and erythematous margins. Exudate levels appeared to be better controlled at this stage (Figure. 6). 

Figure 6: Wound with further separation of the edges in a section of the left edge, with an extension of 4 cm x 1 cm, pearly gray coloration, and erythematous borders, with better control of the exudate. Source: Own, 2022.

The CH maintained the use of an antimicrobial silver dressing as the primary layer, secured with an adhesive support. On December 26, 2022, additional wound edge separation was noted, reaching a depth of 2 cm. The edges were detached from the base with minimal exudate present (Figure. 7).

Figure 7: Further separation of the wound edges, with a depth of 2 cm, edges lifting from the bottom with minimal exudate. Source: Own, 2022.

At this stage, the CH opted to fill the lesion with a hydrofiber dressing containing silver, chosen for its antimicrobial action and stability in both moist and dry conditions. The site was then covered with an outer antimicrobial layer and secured using an adhesive bandage. Ongoing communication with the attending physician supported treatment planning, including the introduction of corticosteroids. Dressing changes were scheduled at 72-hour intervals.

By January 4, 2023 -just over a week later-the wound exhibited reduced depth, increased granulation tissue formation, and minimal exudate (Figure. 8).

Figure 8: Wound with less depth, more granulation tissue, and minimal exudate. Source: Own, 2023.

Residual sutures were observed maintaining edge approximation and were subsequently removed. The dressing protocol remained unchanged, with applications scheduled every 72 hours. One week later, by January 11, 2023, the wound margins appeared healthy, and the wound bed measured approximately 4 cm × 3 cm, with visible granulation tissue and minimal exudate (Figure. 9).

Figure 9: Wound with healthy edges, a bed of 4 cm x 3 cm with granulation tissue and minimal exudate. Source: Own, 2023.

Dermatology recommended tapering the prednisone dosage by 5 mg weekly over four weeks, beginning at 55 mg. For wound management, the CH employed a silver-infused hydrofiber dressing secured with an adhesive bandage. In response to continued lesion activity and suboptimal healing progression, daily magnetotherapy was initiated. The therapy consisted of fifteen 30-minute sessions, calibrated to 200 gauss and 49 Hz. To facilitate continuity of care, the patient was provided with a portable device for home-based application.

On January 16, 2023, the CH initiated simultaneous treatment with magnetotherapy and collagen-based dressings. Following wound cleansing with a sodium hypochlorite solution, a collagen sheet was applied to cover the entire wound bed, leaving a 0.5 cm margin beyond the wound edges. An adhesive dressing was used as a secondary layer, with dressing changes scheduled every three days. This combined approach led to noticeable and accelerated improvements in wound closure. By January 30, 2023, the wound edges were well-adhered to the underlying dermis, and the lesion had reduced in size to approximately 1 cm × 0.5 cm, with minimal exudate. Both the depth and separation of the wound had significantly improved, and the wound bed demonstrated robust, healthy granulation tissue (Figure. 10). 

Figure 10: Lesion with edges adhered to the dermal layers, measuring 1 x 0.5 cm, with minimal exudate, reduced depth, and good-quality granulation tissue. Source: Own, 2023.

The integrated approach combining collagen-based dressings with magnetotherapy contributed substantially to the accelerated healing process. By February 20, 2023, the wound had contracted to a diameter of 0.2 cm, presenting with healthy granulation tissue, absence of exudate, and no reported complications. Collagen-based dressing therapy was maintained in the wound bed. Systemic corticosteroid therapy was discontinued; however, Dermatology confirmed continued tapering of prednisone, with the dose at that time set at 40 mg. Between February 20 and March 27, 2023, the wound remained stable, with no notable changes. Incomplete epithelialization persisted, and the lesion measured approximately 0.5 × 0.2 cm, characterized by healthy granulation tissue, absence of exudate, and no signs of infection (Figure. 11).

Figure 11: Granulation tissue lesion measuring approximately 0.5 x 0.2 cm. Source: Own, 2023.

Low-dose corticosteroid therapy was reinitiated by Dermatology, with a recommended gradual tapering of prednisone at a rate of 10 mg per week. Wound care continued every 72 hours, including cleansing with a sodium hypochlorite solution and the application of collagen-based dressings. Additionally, topical micronutrients -comprising ionic zinc, calcium, magnesium, sodium, and vitamins A and B6- were applied to the wound margins, followed by adhesive dressing coverage.

By March 28, 2023, the wound was being managed with collagen-based dressings in combination with topical micronutrient therapy. However, signs of cutaneous irritation were noted, likely resulting from friction with denim clothing (Figure. 12).

Figure 12: Wound in recovery, seemingly affected by rubbing against denim pants. Source: Own, 2023.

The treatment protocol remained unchanged. On April 10, 2023, the patient’s progress was confirmed, with complete epithelialization of the wound and sustained closure, absent any exudate. Healing was achieved without complications, attributable to the advanced wound care delivered by the CH (Figure 13). No further corticosteroid therapy was indicated, following a final taper to 2.5 mg of prednisone, as previously recommended by Dermatology.

Figure 13: Fully epithelialized wound. Source: Own, 2023.

Discussion

The clinical presentation of PG is notably heterogeneous. In this case, the lesion was morphologically categorized as ulcerative and, due to its atypical progression, further classified as a clinical variant (postoperative). This aligns with the predominant phenotype reported in the literature [1,2], as the lesion originated as an inflammatory pustule at a site of recent trauma—a cesarean section incision. The condition evolved with the development of an erythematous halo extending over previously unaffected skin, followed by central ulceration and severe pain. In this case, the ulcer exhibited an elevated inflammatory border with a bullous configuration, violaceous discoloration, and a secretion-covered base. The lesion progressed asymmetrically -advancing more rapidly on the left side and more slowly on the right- forming a serpiginous pattern consistent with published descriptions [2-4]. Although PG typically manifests on the trunk and lower extremities [1,3], this presentation involved the suprapubic region, arising at a site of surgical trauma following cesarean delivery and associated with wound dehiscence. The diagnosis of PG is primarily clinical, with histopathological evaluation serving as a complementary tool to exclude other differential diagnoses [2]. In this case, Dermatology established the diagnosis based on clinical presentation, which was subsequently reconfirmed by biopsy findings. Additionally, Crohn’s disease and other potential underlying conditions were ruled out during the diagnostic process. Although no specific laboratory markers exist for the diagnosis of pyoderma gangrenosum, leukocytosis—particularly with a predominance of polymorphonuclear cells—and elevated acute-phase reactants are frequently observed [3]. In this case, laboratory testing revealed an increased white blood cell count, supporting the presence of systemic inflammation.

Currently, no standardized clinical guidelines exist for the treatment of PG [13]. Consequently, management relies on suppressing the inflammatory response and implementing optimized wound care to support healing. Although initial improvement may be observed, full remission often requires prolonged complex and challenging treatment [1]. These therapeutic principles were fully reflected in the clinical progression and outcome documented in this case. In this case, the CH oversaw the management and recovery process, tailoring treatment objectives to the lesion’s underlying etiology [14]. A comprehensive wound assessment guided the selection of interventions aimed at promoting epithelialization and minimizing the risk of reinfection. Management included antimicrobial cleansers, topical micronutrients, and advanced primary and secondary dressings. Complementary therapies—such as magnetotherapy—were integrated into a structured wound care regimen. This multidisciplinary, evidence-informed approach proved highly effective in treating pyoderma gangrenosum–related lesions [7].

Therapeutic management of PG remains highly individualized, as no universally effective treatment has been established [13,14]. In most cases, localized wound care serves as an adjunct to systemic therapy, commonly involving immunosuppressive or immunomodulatory agents [4,5]. In this case, treatment combined oral corticosteroids with advanced wound care—incorporating biological and silver-based dressings, alongside magnetotherapy—achieving complete epithelialization within four months. Systemic corticosteroids represent a first-line therapeutic option for PG due to their prompt efficacy, affordability, and ease of administration, with prednisone being the agent of choice [2,3]. In this case, Dermatology initiated treatment with 60 mg of prednisone daily, subsequently tapering the dose in alignment with the patient’s clinical improvement until complete discontinuation upon full resolution of the lesion.

The concurrent use of alternative therapies -specifically magnetotherapy combined with collagen-based dressings- played a key role in promoting accelerated epithelialization through non-invasive mechanisms. These effects were consistently observed during each wound care session conducted by the CH. In this case, magnetotherapy supported wound closure and pain relief, aligning with documented evidence of electromagnetic fields’ influence on cellular regeneration and their physiological and biochemical impact [7, 9]. The integration of pharmacologic interventions with complementary therapies -such as advanced wound care and magnetotherapy- resulted in complete and satisfactory resolution of the pyoderma gangrenosum lesion documented in this case.

Conclusion

This case underscores the complexity of managing pyoderma gangrenosum (PG), a condition that requires prolonged care, specialized wound management, and interdisciplinary collaboration. Timely diagnosis and thorough wound assessment are critical in guiding an effective, adaptable treatment plan. A combination of pharmacologic and complementary therapies -including wound cleansing, biological dressings, collagen-based materials, and magnetotherapy- successfully promoted complete epithelialization and 100% wound closure without complications or continued steroid use. The case illustrates that PG management must be tailored to the wound’s dynamic healing trajectory, using gentle, phase-specific interventions to prevent tissue damage and avoid enlarging the wound cavity. This case contributes valuable clinical evidence supporting innovative advanced wound management techniques in complex PG presentations.

Authors Acknowledgment

The authors would like to express their sincere gratitude to all individuals who contributed to the completion of this work. Special thanks are extended to the team of doctors: Rauff A, Soria T, González D, for their guidance, support, and valuable input throughout the manuscript preparation.

Acknowledgement

No funds, resources or financial support from individuals or grant particulars, so there is no conflict of interest. The author is the only contributor for design, data collection, and preparation of article.

References

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk