AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2642-973X/138
1Laboratory of Applied Nanotechnology of Belousov.
2Kharkiv National Medical University, Ukraine.
3Krasnokutsk Central District Hospital, Ukraine.
*Corresponding Author: A.N. Belousov, Laboratory of Applied Nanotechnology of Belousov and Kharkiv National Medical University, Ukraine.
Citation: A.N. Belousov, E. Yu. Belousova, A.V. Mysyk, (2025), Therapeutic Potential of Biocompatible Nanodevices in Multiple Sclerosis: Results of a Clinical Study, J. Brain and Neurological Disorders, 8(4): DOI:10.31579/2642-973X/138
Copyright: © 2025, A.N. Belousov. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 11 April 2025 | Accepted: 23 July 2025 | Published: 18 August 2025
Keywords: multiple sclerosis; treatment; nanodevice; micromega-B; neurological status assessment; remyelination
Multiple sclerosis (MS) is a significant neurological disorder due to its high prevalence, chronic progression, frequent development of disability, and predominant onset in young individuals. The pathogenesis of MS is primarily explained by the immunopathogenesis hypothesis. Biocompatible magnetite nanoparticles, known for their selective sorption of cell membrane surface proteins, circulating immune complexes, lymphocytotoxin antibodies, and complement system components, have demonstrated potential for immunoreaction. Additionally, these nanoparticles enhance phagocytic activity and improve the leukocyte phagocytosis index, making them promising candidates for MS therapy. The primary objective of this study is to slow MS progression, improve neurological function and overall patient well-being, and mitigate the expansion of demyelinating lesions in the brain.
Materials and Methods: The study included a patient diagnosed with secondary progressive multiple sclerosis in its cerebrospinal form during a phase of clinical exacerbation. Neurological status and disability levels were assessed using the Expanded Disability Status Scale (EDSS), and contrast-enhanced brain MRI was performed. The nanodevice Micromega-B was administered orally as an immunosorbent and immunomodulator, with dosage and treatment regimens tailored to the patient. Assessments of general condition and neurological function were conducted weekly over a six-month period, with a contrast-enhanced MRI scan performed in the fifth month.
Results: Treatment with micromega-B resulted in a measurable improvement in neurological status. Patient experienced reduced stiffness and fatigue in the lower limbs, improved gait and coordination, diminished hand tremors, alleviation of depression and concentration difficulties, restoration of appetite, and enhanced speech function. Throughout the treatment, positive trends in neurological normalization were observed. After six months, the total EDSS score decreased from 210 to 45. The most significant improvements were noted in pyramidal function and coordination, with a reduction in the EDSS Disability Scale score from 6.0 to 5.0. Remarkably, by the fourth month of treatment, contrast-enhanced MRI revealed a decrease in the number of newly formed demyelinating foci for the first time. The observed improvements in neurological status corresponded with MRI findings. The recovery of central nervous system function in MS appears to result not only from the immunosuppressive properties of magnetite nanoparticles but also from the activation of remyelination mechanisms and oligodendrocyte differentiation through enzymatic methylation.
Conclusion: The integration of biocompatible nanodevices into MS therapy holds significant promise. Further refinement and research into the optimal regimen and administration methods of biocompatible magnetite nanoparticles are warranted to maximize their therapeutic efficacy in MS management.
Multiple sclerosis (MS) is a major neurological disorder characterized by its high prevalence, chronic progression, frequent development of disability, and a tendency to affect young adults, with an average onset age of 30 years. The predominant hypothesis regarding the immunopathogenesis of MS suggests a breakdown in immune tolerance, allowing autoreactive cells sensitized to nervous tissue antigens to cross the blood-brain barrier and infiltrate the brain. B lymphocytes recognize myelin and activate T cells, triggering an immune response [1-7]. Activated T and B cells release signaling molecules that recruit additional immune cells, leading to inflammation [8,9]. Plasma cells produce antibodies that target myelin and amplify immune cell recruitment [10,11]. This sustained immune activity enables T and B cells to establish a persistent presence in the central nervous system (CNS), perpetuating neural damage [12,13]. There are two primary hypotheses regarding the pathogenesis of multiple sclerosis (MS). The outside-in hypothesis suggests that immunocompetent cells activated in the periphery infiltrate the brain and initiate an immune response. In contrast, the inside-out hypothesis proposes that primary damage to nervous tissue triggers the expression of damage-associated molecular pattern (DAMP) receptors, leading to immune activation and loss of tolerance to myelin antigens [14]. Plasma cells produce antibodies that actively degrade the protective myelin sheath of nerve cells, resulting in inflammation. Over time, this process leads to scarring, disrupting nerve signal conduction. As a result, neural impulses from the brain fail to reach the limbs and organs, ultimately impairing motor control and bodily functions [15]. The most common initial clinical symptoms include limb weakness and sensory disturbances, vision impairment, urinary dysfunction, and cerebellar ataxia. Currently, pathogenetic treatment for MS primarily relies on immunomodulatory and immunosuppressive therapies that modify disease progression. These treatments operate through various mechanisms, including:
Future therapeutic strategies for MS focus on selective local immunocorrection, remyelination, neuroprotection, enhancement of neuroplasticity and functional relocalization, assessment of the efficacy and safety of cell-based therapies, and personalized treatment selection. Advances in molecular and cellular biology are expected to enable more precise predictions of disease progression and individual responses to therapy, paving the way for a more targeted and effective approach to MS management [16-22]. The progression of inflammation and demyelination in multiple sclerosis (MS) is driven by dysregulation of the immune response, an imbalance between regulatory and effector T cells, activation of B-cell immunity, and microglial involvement. All disease-modifying therapies for MS either deplete T or B cells or modulate signaling pathways critical to immune response regulation [23]. Recent research has highlighted the crucial role of B cells in sustaining chronic inflammation within the central nervous system (CNS). Their functions include autoantibody production, antigen presentation, and continuous activation of T cells within the brain parenchyma. Anti-B-cell therapies such as Rituximab, Ocrelizumab, and Ofatumumab have demonstrated efficacy in both relapsing and progressive forms of MS. Efforts to stimulate remyelination have led to the development of novel monoclonal antibodies, including anti-LINGO and human immunoglobulin M (IgM), which promote myelin repair by enhancing oligodendrocyte differentiation and maturation [24]. A key contributor to axonal degeneration in MS is mitochondrial dysfunction. Several compounds, such as Dimethyl fumarate, Idebenone, and Biotin, show promise in addressing mitochondrial deficits and supporting neuronal survival [25]. Additionally, drugs targeting ion channel redistribution in demyelinated axons such as Lamotrigine, Amiloride, and Fampridine - may help mitigate energy deficits in neurons and axons, potentially improving neural function and reducing neurodegeneration [26]. In recent years, biocompatible nanotechnological agents have gained increasing application in medicine. Since 1998, Ukrainian clinics have officially utilized nanodevices developed by Belousov’s Applied Nanotechnology Laboratory, including the Micromage-B, MCS-B, and ICNB brands (Figure 1) [27]. These nanodevices are based on biocompatible magnetite nanoparticles, whose unique physicochemical properties enable diverse medical applications. They modulate the quantitative and qualitative composition of bodily fluids, influence metabolic and biochemical processes, and regulate cellular energy balance. Their selective sorption activity targets surface proteins of cell membranes, circulating immune complexes, lymphocytotoxic antibodies, and the complement system. Additionally, they enhance phagocytic activity and improve the leukocyte phagocytosis completion index [28], making them effective for immunocorrection. Beyond immune modulation, these nanopreparations impact glycolysis, ion channel activity in cell membranes, and erythrocyte function, while also improving microcirculation and reducing platelet aggregation (Figure 2) [29-31]. Furthermore, they activate antiradical enzyme systems and inhibit lipid peroxidation, contributing to their broad therapeutic potential [32,33].
Figure 1: New official nanomedical devices based on biocompatible magnetite nanoparticles.
Figure 2: Effect of biocompatible magnetite nanoparticles on functional status of erythrocytes and hemorheology.
The findings of these studies provide a solid foundation for developing innovative approaches to the safe and effective use of biocompatible magnetite nanoparticles in the treatment of severe autoimmune diseases, such as multiple sclerosis (MS). The main goal of this research is to slow the progression of MS, enhance the patient's neurological function and overall health, and limit the spread of demyelinating lesions in the brain.
Patient K. was diagnosed with secondary progressive multiple sclerosis (MS), cerebrospinal form, at the stage of clinical exacerbation. The patient exhibited severe spastic tetraparesis, with greater involvement of the lower limbs, resulting in impaired mobility. Additionally, the patient presented with significant urinary-ataxic syndrome, as well as sphincter and sensory dysfunction. MRI scans revealed multifocal diffuse demyelinating brain lesions (more than 30), indicative of the active disease phase, along with a diffuse atrophic process in the cerebral cortex. Over the year preceding study inclusion, the patient experienced an average of 1.0 relapse, with an Expanded Disability Status Scale (EDSS) score of 6.0. The disease had been progressing for 24 years since the onset of initial symptoms. For 14 years, the patient underwent regular treatment with vascular and metabolic agents, in conjunction with hormonal therapy. Despite this, the disease transitioned to a secondary progressive form after 6 years, prompting the introduction of the immunosuppressive drug Teriflunomide into the treatment regimen.
However, despite ongoing treatment efforts, the patient’s general condition continued to deteriorate, and the neurological status remained unstable. MRI scans over the past four years showed a progressive increase in the number of new demyelinating lesions in the brain. In light of the above, the patient's treatment regimen was augmented with the addition of Micromage-B [34]. Micromage-B is an oral nanodevice officially registered by the Ministry of Health of Ukraine. It consists of a powdered form of magnetite (Fe₃O₄) nanoparticles, developed for the prevention and treatment of various conditions, as well as to enhance the body’s resilience to adverse environmental factors. As a nanotechnology-based product, Micromage-B contains magnetite nanoparticles ranging in size from 6 to 12 nm. The therapeutic effect of Micromage-B is primarily driven by the sorption mechanism and the influence of a constant magnetic field on cellular and subcellular structures induced by the magnetite nanoparticles. These nanoparticles have a sorption surface area of 800 to 1200 m²/g and generate a magnetic field strength of 300-400 kA/m. The main target of Micromage-B is the microenvironment of the cell's aqueous spaces and surface membrane proteins. Through selective sorption, the magnetite nanoparticles alter the quantitative and qualitative composition of cell surface proteins. Additionally, the constant magnetic field affects the mobility and orientation of hydrogen protons within the cell’s aqueous microenvironment (Figure 3).
Figure 3: The effect of magnetite nanoparticles on hemolysis processes by changing the polarization structure of the aqueous sector of the erythrocyte microenvironment.
This mechanism triggers the hydrolysis of the phosphate residue of ATP, leading to alterations in the cell's transmembrane exchange and metabolism, and modifying its susceptibility to various stimuli. The nanodevice enhances the cell's adaptive mechanisms and optimizes the function of cellular organelles. It accelerates repair processes at the membrane and macromolecular levels, significantly boosts intracellular synthetic reactions, and enhances the compensatory capabilities of organelles within the renal glomerulus cells and the epithelial cells of the proximal and distal nephron segments. This structural improvement is reflected in enhanced bioenergetic support for synthetic intracellular processes, as well as an increase in the repair and adaptive functions of nephrons. By enhancing redox phosphorylation processes, which meet the energy demands of synthetic reactions in the membrane and macromolecular components of hepatic cells, Micromage-B acts as a direct activator of reparative intracellular processes in hepatocytes, promoting glycogen synthesis. This property makes it an effective hepatoprotective agent for treating both acute and chronic liver conditions. Micromage-B acts as a potent erythropoiesis stimulator, rapidly restoring hemoglobin levels in the blood. It also stimulates the synthesis of pulmonary surfactant, improving lung tissue stretchability and elasticity, thereby enhancing lung stability against both internal and external stressors. This effect is mediated by increased activity of alveolar macrophages. Clinically and in laboratory settings, Micromage-B enhances microcirculation and blood rheological properties by stabilizing erythrocyte membrane bioelectric charge, exhibiting a significant immunomodulatory effect, and selectively exerting bacteriostatic effects against pathogenic microflora while preserving normoflora. It impedes the growth and proliferation of various fungi and promotes the growth and activity of lactic acid bacteria in the intestines, thereby enhancing the efficacy of antibacterial and antifungal agents by 2-3 times. These attributes enable Micromage-B's effective application in dysbacteriosis and candidiasis treatment. Micromage-B nanoparticles adsorb toxic substances and circulating immune complexes, significantly enhancing the treatment efficacy of various allergic diseases, autoimmune processes (such as rheumatoid arthritis, acute and chronic polyarthritis, eczema, etc.), and acute poisoning. Micromage-B moderately improves renal blood flow, exerting a mild diuretic effect.
Magnetite nanoparticles in Micromage-B, with their intrinsic magnetic properties, aid in the breakdown and dissolution of kidney and bile duct stones, allowing them to be eliminated from the body as magnetically responsive crystalline forms through the excretory system. In addition to this, Micromage-B plays a key role in normalizing blood lipid and protein levels. It also impacts factors involved in atherogenesis, helping to slow the progression of atherosclerotic processes. The constant magnetic field generated by the magnetite nanoparticles reduces the release of excess aggressive mediators from macrophage cells into the bloodstream, leading to notable anti-inflammatory and mild analgesic effects. Furthermore, Micromage-B regulates antioxidant enzyme activity, absorbs products of lipid peroxidation, and helps restore the balance between antiradical and pro-radical substances. Under its influence, monocytes actively produce tumor necrosis factor (cachexin), which exerts cytotoxic and cytostatic effects on tumor cells. When applied topically (as powders, ointments, or aqueous colloidal solutions), Micromage-B accelerates the healing of mucous membranes and skin wounds, promoting the transition from wet tissue necrosis to dry. Micromage-B is non-toxic and does not interfere with organ or systemic function [35,36].
The dosing regimen for Micromage-B entails 500 mg daily for the first month, 500 mg every other day for the second month, and subsequently, 500 mg once every three days. The selection of Micromage-B dosage and regimen is tailored individually, considering the patient's rate of improvement and neurological recovery.
The study monitored changes in neurological status using a modified version of the Multiple Sclerosis Patient Assessment Scale [37,38], which evaluates the severity of motor impairments alongside other nervous system damage indicators. Disability was quantitatively assessed using Kurtzke's online EDSS calculator [39]. Manifestations of cerebral demyelination foci were examined through contrast-enhanced MRI.
The patient's overall condition and neurological status were assessed every 7 days over a 6-month period. As per the protocol, a contrast-enhanced MRI of the brain was conducted annually, aligning with the 5th month of Micromage-B usage.
The progression of neurological changes was evaluated using a modified scale. One week after starting Micromage-B, a significant improvement in the patient's neurological condition was observed. The patient reported a substantial reduction in lower limb stiffness and fatigue. Objectively, there were notable improvements in gait and coordination, a decrease in hand tremors, complete resolution of depression and concentration issues, restoration of appetite, and enhanced speech. Positive trends in the normalization of neurological status were maintained throughout the entire duration of Micromage-B treatment. Table 1 shows the evaluation of the neurological status of a multiple sclerosis patient before and after six months of Micromage-B therapy.
| 1. Movements (pyramidal system) | ||||||
| Input data | Six months after application Micromage-B | Clinical manifestations | ||||
| Arm | Leg | Arm | Leg | |||
| 0 | 0 | 0 | 0 | Norma | ||
| 5 | 10 | 5* | 10* | Absence of loss symptoms, revival of tendon reflexes, enlargement of reflexogenic zones, clonus, presence of pathological signs, anisoreflexia, (absence of paresis) | ||
| 10 | 20 | 10 | 20 | Raises a limb independently, full volume of active movements, signs of pyramidal lesion, overcomes not only the gravity of his own limb, but also an additional obstacle of moderate strength, positive Barre-Rusetsky's symptom | ||
| 15 | 40 | 15 | 40 | Raises a limb independently, the volume of active movements is full, cannot hold a limb in a given position for a long time, and cannot overcome an additional obstacle. | ||
| 20* | 60* | 20 | 60 | Can pull a limb off the plane, the amount of active movement is limited, cannot hold a limb in a given position. | ||
| 40 | 80 | 40 | 80 | Cannot detach a limb from the plane, active movements in the joints of the fingers, ankle and wrist, elbow, knee joints are possible only on the plane. | ||
| 50 | 100 | 50 | 100 | Complete absence of movement (paralysis) | ||
| 2. Sensitivity | ||||||
| Before | After | (a) superficial sensitivity | ||||
| 0 | 0* | Norma | ||||
| 5 | 0 | Paresthesias, burning sensation, numbness, coldness of a limb (no objective disorders) | ||||
| 10* | 10 | Hyperesthesia or hypoesthesia | ||||
| 15 | 15 | Anesthesia phenomena | ||||
| b) deep sensitivity | ||||||
| 0* | 0* | Norma | ||||
| 10 | 10 | Disorder of joint and muscle feeling in small joints | ||||
| 20 | 20 | Disorder of joint and muscle feeling up to the level of the middle joints (wrist, ankle) | ||||
| 40 | 40 | Disorder of joint and muscle feeling up to the level of large joints (elbow, shoulder, knee, hip) | ||||
| 3. Coordination | ||||||
| 0 | 0 | Norma | ||||
| 10 | 10* | Unsteadiness, swaying in the sensitized Romberg's test while standing on one leg, mild intensional trembling (in the complicated test), slight ataxia in the heel-knee test, deviation when walking with eyes closed. | ||||
| 40* | 10 | Unsteadiness in simple Romberg's pose, atactic gait with open eyes and legs spread wide apart, "drunkenness," moderately pronounced intensional tremor and ataxia in the heel-knee test. | ||||
| 100 | 100 | Because of ataxia, the patient cannot move without assistance, sharp hypotonia of muscles, intensional shaking of the head, trunk, coarse - upper extremities, coarse ataxia during heel-knee test, trembling of upper extremities when trying to perform purposeful movement, chanted speech. | ||||
| 4. Psycho-emotional sphere | ||||||
| 0 | 0* | Norma | ||||
| 10 | 10 | Mild impairment of the intellect in combination with euphoria, rapid change of mood, neurasthenic syndrome. | ||||
| 20* | 0 | Euphoria, depression, decreased criticism of one's condition, decreased memory. | ||||
| 100 | 100 | Severe mental disorder, complete intellectual disintegration, Korsak's syndrome, etc. | ||||
| 5. Nystagmus | ||||||
| 0 | 0* | Norma | ||||
| 5 | 5 | Nystagmus is detected only in the extreme leads (degree 1) | ||||
| 10* | 10 | Nystagmus when looking straight ahead (degree 2) | ||||
| 15 | 15 | Sharp beating nystagmus, nystagmus in both directions, even toward the slow component (3rd degree) | ||||
| ||||||
| 0 | 0* | Norma | ||||
| 10* | 10 | Impulsive urges, inability to hold urine for a long time, difficulty urinating | ||||
| 20 | 20 | Urinary incontinence, urinary retention, intermittent urination disorders, persistent constipation | ||||
| 7. Sexual function | ||||||
| 0 | 0* | Norma | ||||
| 5* | 5 | Decreased sexual activity in men (intermittent impotence), sexual coldness in women | ||||
| 10 | 10 | Total impotence, menstrual disorders in women | ||||
| ||||||
| 0 | 0 | Norma | ||||
| 5 | 5 | Disturbance of vascular pattern, narrowing of arteries, dilation of veins, changes on fluorescence ophthalmoscopy | ||||
| 10* | 10* | Partial optic atrophy (bitemporal pallor), optic neuritis | ||||
| 15 | 15 | Complete atrophy of the optic nerve | ||||
| ||||||
| 0 | 0 | Norma (vision within 1.0 or myopia) | ||||
| 5 | 5 | Occasional blurring of vision, rapid fatigue when reading and performing work without impaired visual acuity | ||||
| 10* | 10* | Visual acuity from 0.9 to 0.7 | ||||
| 15 | 15 | Visual acuity from 0.6 to 0.4 | ||||
| 20 | 20 | Visual acuity from 0.3 to 0.1 | ||||
| 25 | 25 | Visual acuity 0.1 and below | ||||
| 100 | 100 | Blindness in one or both eyes | ||||
| ||||||
| 0 | 0* | Norma (absence of subjective and objective symptoms) | ||||
| 5* | 0 | Concealed insufficiency, without visible dysfunction of one of the oculomotor nerves, inter-nuclear ophthalmoplegia syndrome | ||||
| 10 | 10 | Mild visible impairment, visible insufficiency of one or more nerves, diplopia, ptosis, anisocoria | ||||
| 15 | 15 | Convergent or divergent strabismus | ||||
| 20 | 20 | Complete ophthalmoplegia (in one or both eyes) | ||||
| 11. The trigeminal nerve | ||||||
| 0* | 0* | Norma (absence of subjective and objective symptoms) | ||||
| 5 | 5 | Subjective sensations in the form of pain, numbness, sense of "creeping chills", oppression in the face. | ||||
| 10 | 10 | Objective signs of lesions, hypoesthesia, loss or decrease in the corneal reflex. | ||||
| 20 | 20 | Severe anomalies with loss of trigeminal nervous functions, with or without neuralgic disorders. | ||||
| 12. The facial nerve | ||||||
| 0 | 0* | Norma | ||||
| 5* | 0 | Moderate weakness of facial muscles (eye closes completely, but cannot actively close it), asymmetry of frontal and nasolabial folds | ||||
| 10 | 10 | Moderate weakness of mimic muscles (lagophthalmus, positive Bell's symptom, facial asymmetry in grinning), with preservation, to some extent, of mimic movements | ||||
| 20 | 20 | Complete paralysis of facial muscles | ||||
| ||||||
| 0 | 0* | Norma | ||||
| 5* | 5 | Mildly pronounced bulbar phenomena (gagging when taking liquid food, change in speech, without gross organic symptoms of prolapse) | ||||
| 10 | 10 | Severe dysphagia, dysarthria, decreased soft palate and posterior pharyngeal wall reflexes | ||||
| 100 | 100 | Complete bulbar paralysis | ||||
| ||||||
| 0* | 0* | Norma | ||||
| 5 | 5 | Conversational speech at a distance of 4 to 6 m, whispered speech at a distance of 1 to 3 m. | ||||
| 10 | 10 | Speech - from 2 to 4 m, whisper - from 0.5 to 1 m. | ||||
| 15 | 15 | Spoken speech 2 m or less, whispered speech 0 to 0.5 m | ||||
| 20 | 20 | Complete deafness in one or both ears | ||||
| Total: | Total: | |||||
| 210* | 45* | |||||
Table 1: Assessment of Neurological Status Scale for Patient K. with Multiple Sclerosis.
Note: * - estimated scores of the neurological status before and after using the Micromage-B.
The data presented in Table 1 illustrate a positive trend in normalizing neurological status following 6 months of Micromage-B usage. Initially, the total points amounted to 210, which decreased to 45 after the 6-month period, indicating a reduction of 165 points. The most significant improvement was observed in the assessment of the pyramidal system and coordination. Additionally, the EDSS disability scale score decreased from 6.0 to 5.0. A contrast-enhanced MRI of the brain conducted after 4 months of Micromage-B usage revealed a decrease in the number of new demyelination foci in the brain for the first time. The favorable progression of neurological status correlated with the brain MRI findings.
Upon analyzing the collected data, particular attention should be given to the observed positive clinical effects attributed to immunosorption and the active contribution of Micromage-B's magnetite nanoparticles to neurological status restoration. This effect may be attributed to remyelination processes and oligodendrocyte differentiation. Oligodendrocytes, a type of neuroglial cell, form the myelin sheath around neurons in the central nervous system (CNS). The molecular mechanisms underlying cell differentiation and specialization remain complex and poorly understood, presenting a challenging area in cell and developmental biology. The development and maturation of various cell types continue to pose significant research challenges.
A recent study has shown that one of the key mechanisms of oligodendrocyte maturation involves enzymatic methylation, specifically the addition of a methyl group (-CH3) to the N6 nitrogen atom in the adenosine base, a process known as m6A-methylation. Although this modification may seem subtle, it can profoundly influence subsequent stages of protein biosynthesis. The role of m6A-methylation has been demonstrated in various processes associated with oligodendrocyte maturation [40]. The universal donor of methyl groups in the body is S-adenosylmethionine, which is synthesized through the interaction of the amino acid methionine and ATP. Micromage-B activates glycolysis, leading to a significant increase in ATP production [41,42], and promotes the formation of the reduced form of the coenzyme NADPH2, aiding in the reduction of oxidized glutathione [43]. These conditions create an environment conducive to the initiation of enzymatic methylation processes, likely enhancing the action of magnetite nanoparticles (Micromage-B). This, in turn, supports oligodendrocyte differentiation and the remyelination process. Additionally, it is important to note that these nanoparticles alter the aqueous environment of the cellular microenvironment [44], triggering ATP hydrolysis, energy release, and the formation of ADP. For a more comprehensive understanding of how biocompatible magnetite nanoparticles (Micromage-B) influence remyelination, refer to Figure 4.
Figure 4: Mechanism of the effect of magnetite nanoparticles on oligodendrocyte maturation.
Due to the positive changes in the neurological status, it was determined that continuing the administration of Micromage-B at the prescribed dosage was appropriate. The therapy was further supplemented with a comprehensive rehabilitation exercise program aimed at accelerating the recovery of physical, cognitive, and psychosocial functions in the patient with MS.
The results of the study expanded the clinical applicability of biocompatible magnetic nanoparticles in the treatment of severe autoimmune diseases [45-48]. The use of the Micromage-B nanopreparation in the treatment of multiple sclerosis (MS) showed significant positive clinical effects. Throughout the treatment period, notable improvements were observed in the normalization of the neurological condition. After six months of treatment, the overall score dropped from 210 to 45, with the most significant improvements seen in the pyramidal system and coordination assessments. The EDSS Disability Scale score decreased from 6.0 to 5.0. For the first time, contrast-enhanced brain MRI revealed a reduction in the number of new demyelination foci by the fourth month of Micromage-B administration. The improved neurological condition correlated with positive results from brain MRI scans. The restoration of central nervous system function in MS is attributed not only to the immunosuppressive effects of magnetite nanoparticles but also likely to the activation of remyelination mechanisms and oligodendrocyte differentiation through enzymatic methylation. The design and use of biocompatible magnetite nanoparticles to enhance MS treatment efficacy require further refinement and study. The incorporation of biocompatible nanodevices in the comprehensive treatment of MS is a promising innovation, with plans to integrate magnetite nanoparticles into treatment protocols for MS in the near future [49-51].
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
