AUCTORES
Globalize your Research
Case Report | DOI: https://doi.org/10.31579/2578-8868/050
1 Resident, Department of neurosurgery, Bangabandu Sheikh Mujib MedicalUniversity, Shahbag, Dhaka, Bangladesh
2 Professor, Department of neurosurgery, Bangabandu Sheikh Mujib MedicalUniversity, Shahbag, Dhaka, Bangladesh
*Corresponding Author: Bipin Chaurasia, Resident, Department of neurosurgery, Bangabandu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
Citation: Nwoshin Jahan, Nath HD, Mahbub AA, Arifin SA, Baniya P, et al. (2019) Pineoblastoma at Right Frontotemporal Sellar Suprasellar and Parasellar Region: A Rare Case Report. Neurosci Neurol Surg. 4(1); Doi:10.31579/2578-8868/050
Copyright: © 2019 Jahan N, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 28 May 2019 | Accepted: 07 June 2019 | Published: 12 June 2019
Keywords:
Pineoblastoma is a tumor derived from primitive neuroectodermal cells. It is a highly malignant tumor in pediatric age groups. The prognosis of pineoblastoma is very poor than other supratentorial primitive neuroectodermal tumors (PNET). Pineoblstoma arises from pineal parenchyma. We report a case of 2 years boy with history of several episode of convulsion and gradual weakness of left side of body with altered level of consciousness. On MRI (magnetic resonance imaging) it revealed a mixed intensity lesion on right frontotemporal region mainly in the frontal and temporal base. After evaluation we did right frontotemporal craniotomy and debulking of tumor histopathology revealed pineoblastoma which was confirmed by immunohistochemistry.
Primitive neuroectodermal tumors (PNETs) are a group of highly malignant tumors composed of small round cells of neuroectodermal origin. Cranial PNETs are commonly located infratentorially in the cerebellum and are rarely supratentorial. PNET and pineoblastoma both are account for 4.8% & 0.6% of childhood brain tumor [1]. These tumors are common primary central nervous system tumors in children, but they are extremely rare in adults, representing less than 0.5% of all intracranial tumors. Pineoblastomas arise from pineal parenchyma which are a category of supratentoreal PNET. Though pineoblastoma arise from pineal gland we report a case of pineoblastoma which arises from sellar suprasellar area with extension to anterior frontal and temporal base. There are no published case of pineoblastoma which arises from sellar suprasellar area as a primary site. In contrast there are some published series of recurrence of pineal tumor in suprasellar area after removal of tumor from pineal region [2].
Case Report
A two years old boy from remote area of Bangladesh was admitted in the department of neurosurgery, Bangabandhu Sheikh Mujib Medical University with the complaints of one episode of seizure which was tonic clonic in nature, involved all four limbs, persisted for 5 to 6 minutes with no history of tongue biting, frothing, upward rolling of eyeball or no history of involuntary passage of urine and faeces. Following the event, he lost his consciousness for an hour. Then he was transferred to nearby hospital and treated conservatively. After that, he was seizure free for one year without any medication. Then his mother noticed progressive weakness of the left side of his body and baby gradually became lethargic & reluctant to feed with occasional vomiting.
On examination, baby was conscious and irritative, with spontaneous eye opening & following the sound of mother and object. Pupil was reacting to light. Ocular motility was normal. OFC (Occipito Fronatal Circumference) was 52 cm. Other examination wasn’t done.
We did CT (computed tomography) scan (Figure -1b) and MRI of Brain (Figure 1a) with contrast which revealed a mixed density lesion involving the right front temporal region with heterogeneous contrast uptake. MRI of Brain with contrast showed mixed intensity lesion with solid and cystic component involving front temporal region.
After proper evaluation he underwent right extended front temporal craniotomy and removal of tumor as far as possible. After surgery he symptomatically improved and baby became playful. Histopathology (figure 1c) report reveals pineoblastoma which was confirmed by immunohistochemistry. On 10th postoperative day we discharged the patient with advice to consult with oncologist. Postoperative image showed significant removal of tumor (Figure d).
Discussion
Pineoblastoma is extremely malignant tumor which is locally invasive. It is WHO grade IV tumor which is about <1% of pediatric brain tumors [2,3]. Pineoblastomas are morphologically identical to PNETs in other locations and are similar in their tendency to disseminate through CSF (cerebrospinal fluid) pathway as it is locally invasive so it’s a great challenge to treat such case. The prognosis of pineoblastonma is usually very poor. Several clinical studies have noted that there are important differences in clinical responses to treatment among groups of patients with PNETs arising at different anatomic sites [4] and the reasons for this variations are largely unknown. The location of the PNETs as well as extent of disease at presentation and choice of surgical resection has major importance. Successful treatment requires multimodal approaches with surgery, chemotherapy and radiotherapy. Due to deleterious effect of radiotherapy on developing brain, it is avoided under three years of children [5]. Most of the cases of pineoblastoma present with hydrocephalus. So CSF diversion procedure is another surgical option. VPS (ventriculoperitoneal shunt) & ETV (endoscopic third ventriculoscopy) are common procedure but ETV is most commonly accepted method. Gangemi et al. consider that ETV is not only useful for the treatment of hydrocephalus but also helpful in investigating cells markers, and taking a biopsy [6]. In our case there was mild hydrocephalus. Pineal region was free from tumor .On MRI & CT scan with contrast there was no tumor in the pineal region. So our initial diagnosis was a case of PNET. We didn’t go for any diversion procedure. Rather after optimization we directly went for surgery. Partial decompression of tumor was done due to vessel encasements and severe bleeding. Post-operative period was uneventful & patient improved clinically following surgery. For further management patient was referred to Oncology department.
Survival rate of pineoblastoma is very poor with a median survival of 20 months. Five year survival rate is only 10%. Parikh et al. reported the median overall survival was 34.5 months (range 4.7-183.5) [3]. The prognostic factors of improved survival rates are (1) increased age at presentation (older than 3 years), (2) gross total resection (v/s subtotal or biopsy), (3) lack of disseminated disease and (4) craniospinal radiotherapy more than 40 Gy [7]. The reason of reporting this case is its extreme rarity and very few published cases of pineoblastoma arising from other than pineal region.
Conclusion
Pineoblastoma is very uncommon tumor .Very few cases have been reported in literatures. Those reported cases are mostly from pineal region. Sellar suprasellar pineoblastoma is not reported frequently. As the disease is very malignant surgical decompression, post-operative radiotherapy and chemotherapy increase the median survival rate somewhat. So early diagnosis and treatment is mandatory for the patients’ management and overall survival.
Declaration
Authors’ contributions:
Dr. Haradhon Deb Nath: Conception, diagnosis and design, Radiological diagnosis and Final approval of manuscript
Dr. Nwoshin Jahan, Bipin chaurasia: Manuscript preparation, Technical revision, Maunscript editing and revision
Dr.Nwoshin Jahan, Dr. Abdullah al Mahbub, Dr.Shansul Al Arefin, Dr. Satish Kumar Shah, Dr.Purushottam Baniya: Literature search
Acknowledgement: None
Funding Support and Sponsorship: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Conflicts of Interest: There are no conflicts of interest.
Patient Consent: An informed written consent was obtained from the patients parents.
Ethics Approval: There is no ethical issue in this paper.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
