Evaluation of the Phytochemicals and Antioxidant Properties of Waste from Maize (Zea mays) and Millet (Pennisetum glaucum) in Pap Production

Review Article | DOI: https://doi.org/10.31579/2637-8914/340

Evaluation of the Phytochemicals and Antioxidant Properties of Waste from Maize (Zea mays) and Millet (Pennisetum glaucum) in Pap Production

  • Ofoedum A.F 1*
  • Owumanam C.I 1
  • Uyanwa N.C 1
  • Dike, B.C 1
  • Anyanwu Victor 1
  • Ofoedum, S.L 2

1Department of Food Science and Technology, School of Engineering and Engineering Technology, Federal University of Technology, Owerri, PMB 1526, Imo State, Nigeria.

2Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka Anambra State.

*Corresponding Author: Ofoedum, A.F, Federal University of Technology, Owerri, PMB 1526, Imo State, Nigeria.

Citation: Ofoedum A.F *, Owumanam C.I, Uyanwa N.C, Dike, B.C, Anyanwu Victor., et all., (2025), Evaluation of the Phytochemicals and Antioxidant Properties of Waste from Maize (Zea mays) and Millet (Pennisetum glaucum) in Pap Production, J. Nutrition and Food Processing, 8(10); DOI:10.31579/2637-8914/340

Copyright: © 2025, Ofoedum, A.F. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 17 November 2025 | Accepted: 24 November 2025 | Published: 28 November 2025

Keywords: phytochemicals; antioxidants properties; maize waste; millet waste; protein

Abstract

Background: The study was carried out to access the phytochemical and antioxidant properties in wastes material left after maize and millet grain processing. The waste mash was hygienically collected immediately after processing and transferred to the laboratory for analysis. The waste was sundried and packaged. 

Methods: Standard analytical procedure was followed to analyze the phytochemical and assaying of antioxidant properties of the waste. The data was subjected to statistical analysis. 

Results: The protein content of the millet scored 15.45% while the maize gave 11.40%. The crude fibre content of the maize 7.93% was significantly higher than that of the millet 5.02%. The total phenol of the maize left over mash 69.87 mg per 100g was significantly higher than that of millet 55.28 mg per 100g, while the total flavonoids of maize 253.93 mg per 100g was higher than that of the millet 196.08 mg per 100g. At 10 mg per dl maize waste recorded 68.73; millet 50.43 and gallic acid scored 78.59. The 2,2 Diphenyl-1-picrylhydrazyl (DPPH) reduction activity of the wastes were comparable to the standard, the maize waste had 93.30 mg per dl while millet had 91.38 mg per dl. 

Conclusion: Wastes from maize and millet are good sources of protein, crude fibre and the extracts are rich in bioactive compounds.

1.Introduction

Rice is a major staple cereal all over the world, especially in many Asian countries and also regarded as a natural gluten-free and hypoallergenic ingredient [24]. Food and Agricultural organization (FAO) reported that the global production of rice reached 723 million tons in the year 2011 [6]. By the 20th century, progress of grain processing technology made large-scale production of milled grains possible. Milling removes the outer parts such as bran and germ to produce milled rice which consists mainly of starch and endosperm which starch predominates.  Milled rice is the form of rice most people consume, the germ and bran which are normally removed from brown rice to obtain milled rice contains most of the dietary fibre, minerals, vitamins, fat and phytochemicals of rice grain [8]; [15].  Brown rice is recognized for its high dietary fiber content and elevated levels of essential vitamins and minerals compared to milled (white) rice. It also contains significant amounts of flavonoids and phenolic compounds, which contributes to its antioxidant properties [27]. Due to its minimal milling process, which retains the germ and bran which are the primary sources of vitamins E and B brown rice has gained preference over white rice. Additionally, it is a valuable source of nutrients such as thiamine (vitamin B1), phosphorus and niacin and has been associated with a lower mean glycemic index (55) relative to white rice (64) [7]. 

Germinated brown rice (GBR) is produced by soaking the whole kernel of brown rice to germinate into white blotches on the kernel. The water helps stimulate the enzyme within the rice grain. During the process of germination, several biochemical processes take place due to the activation of various enzymes. These processes lead to changes in the nutritional and chemical compositions of germinated rice [18]. Germinated brown rice (GBR) is a promising raw material due to its elevated levels of γ-aminobutyric acid (GABA), phenolic compounds, flavonoids, vitamins, and minerals that accumulate during germination [13]. Pasta is a staple food widely consumed across the globe due to its versatility, affordability, and sensory appeal [9]. Pasta products are traditionally manufactured from durum wheat semolina, known to be best raw material suitable for pasta production. However, conventional pasta made entirely from refined wheat flour is often limited in essential nutrients, dietary fiber, and bioactive compounds [20]. This traditional cereal based food is a result of dough or moisture enriched flour, shaped in various forms spaghetti, macroni and noodles. Pasta has become recognized as a healthy food, with a low-fat content, no cholesterol and a low glycaemic index [4]. Despite its increasing popularity, constant demands by consumers for a healthier lifestyle have encouraged food scientists and industrial producers to overcome the traditional boundaries for pasta making, researching new and different ingredients for pasta manufacture. This has prompted growing interest in functional pasta formulations enriched with alternative ingredients. Nowadays, it has become important to improve the quality of pasta by the addition of other healthy ingredients which are rich in protein, dietary fibre, vitamins, micronutrients and antioxidants. There is therefore a need for pasta produced from composite flours of germinated brown rice and wheat.

In this study, efforts were made to develop pasta with healthful composite flours by supplementing wheat flour with germinated brown rice (GBR) flour and to evaluate the bioactive components, nutrients and sensory attributes of pasta produced from wheat–GBR composite flours at varying germination durations of 12, 24 and 36 hours.

2. Materials and Methods

2.1. Source of Raw Materials

The paddy rice (FARO 57) used for this study, was obtained from Ebony Agro Industries, Ikwo, Ebonyi State, Nigeria. The paddies were used as raw materials for processing germinated brown rice flours (Figure 1). The additives used were procured locally from various shops in Owerri.

All the chemicals used in the analysis were of analytical grade.

2.2. Methods

2.2.1. Production of Germinated Brown Rice

Before being exposed to the germination processes, rice paddies were spread out on the lab floor for forty days at room temperature (30°C ± 2). Germination was carried out according to [25]. A laboratory rice husker (SATAKE, Australia) was utilised to dehusk the paddies. After being sterilised for 30 minutes in 0.1% NaClO, the dehulled rice grains were rinsed five times with distilled water on a stainless-steel tray. The rice kernels were covered with the second layer of the moist jute bag. For 12, 24, and 36 hours, germination was conducted at 35 °C in a lab cabinet incubator (Gulfex Scientific DNP-9082, England). Distilled water was sprayed every six hours during germination. Following germination, the samples were dried to a moisture content of less than 13% at 50 °C in a hot air oven (Gulfex Scientific DHG 9202, England). In order to obtain germinated brown rice flour (GBRF), the dried rice was ground, sieved through a 100-mesh screen, and kept in an airtight container for additional analysis.

                                                                                            

                                                                                      Figure 1: Production of germinated brown rice flour.

2.2.2. Wheat-Germinated Brown Rice Composite Flour Pasta Formulation

Composite flour was prepared by blending wheat flour with the three germinated brown rice flours (12, 24 and 36 h) in the ratios of 70:30 and 50:50 and the 100% wheat serving as the control. For preparation of pasta, a blend of ingredients (Table 1) were mixed with water to 35%. The pasta for further analysis were extruded in a metal extruder attachment of the pasta machine (Brabender KE 19, Germany) fitted with an adjustable die followed by cutting, using 100% wheat flour (for control sample) and respective mixtures of wheat flour with germinated brown rice at different substitution levels according to the procedures given by [22]. with slight modifications. After preparation of pasta, drying of pasta was carried out in hot air oven at 60 ºC for 5 h to attain moisture content of 12% then stored in airtight containers.

IngredientsQuantity
ControlS1 (12 h)S2 (12 h)S3 (24 h)S4 (24 h)S5 (36 h)S6 (36 h)
Wheat flour (g)100705070507050
GBR flour (g)0305030503050
Water (ml)31313131313131
Oil (ml)5555555
Salt (g)1111111
Guar gum (g)0222222

Table 1: Formulation of composite flour pasta.

2.3. Analytical Methods

2.3.1. Determination of Bioactive Contents

Total phenololic content (TPC), total flavonoid content (TFC), and gamma amino butyric acid (GABA) content are among the parameters that were found. In order to determine TPC and TFC, extracts were made using 95% ethanol and a slightly modified version of the procedure described in [21] utilising the generated pasta. The solvent from the extracts was evaporated under reduced pressure using a rotary vacuum evaporator (Buchi Rotary Evaporator, Model R-124).

2.3.1.1. Determination of Total Phenolic Content (Folin-Ciocalteu Method)

Folin-Ciocalteau reagent (FC reagent) was used to determine the TPC of the extract as described by [17], with slight modifications. The absorbance of the reaction mixture was measured at 765 nm using UV-Visible spectrophotometer (Genway 6305, England). The TPC was extrapolated from the calibration curve using gallic acid as standard. 

A calibration curve was prepared using gallic acid standard solutions (0-100 µg/mL) and the TPC of the samples were calculated from the standard curve and expressed as milligrams of gallic acid equivalents per gram of sample (mg GAE/g).

2.3.1.2 Determination of Total Flavonoid Content (TFC)

The TFC was measured using the method of [10] with slight modifications. The absorbance was measured at 510 nm using a UV-Visible spectrophotometer (Genway 6305, England). A calibration curve was prepared using quercertin standard solutions (0-100 µg/mL) and results expressed as milligrams of quercetin equivalents per gram of sample (mg QE/g).

2.3.1.3 Determination of gamma-amino butyric acid contents. 

This was done using the method of [23]. Five grammes of the pasta samples were measured for extraction after they had been ground to fit through a 0.425 mm standard mesh filter. The milled pasta was combined with 20 mL of 80% ethanol, vortexed for two minutes, and centrifuged for fifteen minutes at 10,000 rpm to complete the extraction. 40 μL of 2-mercaptoethanol, 1 mL of 0.054% o-phthaldialdehyde solution, and 0.4 M borate buffer were added to the supernatant to bring the volume to 10 ml. For the gradient run, high-performance liquid chromatography (Model 363, Varian, Inc. Scientific Instruments, USA) was employed. By comparing the area under the curve with the standard GABA (Fluka Analytical, Jiangsu, China), the GABA content was ascertained. The amount of GABA was expressed as mg/100 g of pasta (dry basis).

2.3.2. Proximate Analysis

The pasta samples were milled using hammer mill and proximate composition namely moisture, ash, protein, fat, dietary fibre and carbohydrate were determined according to the Official Methods of Analysis of [3]. The moisture and ash were determined by using gravimetry, nitrogen value (N) by Kjeldahl, the crude protein (N x 6.25), fat (solvent extraction with petroleum ether), total dietary fibre (enzymatic gravimetric method) and total carbohydrate by computation methods. 

2.3.3. Determination of Vitamins 

The [2] technique was used to determine thiamin (B1), riboflavin (B2), niacin (B3), vitamin B6, vitamin B9, and vitamin E. The 5 g sample was extracted, digested, and finely homogenised. Niacin was extracted using 50 cc of 1 N H2SO4 for 30 minutes, while thiamin, riboflavin, and B6 were extracted using 0.1 N HCl at 121 °C. The absorbance of the resulting solution was measured at 430, 510, 470, 470, and 520 nm wavelengths for B1, B2, B3, B6, B9, and E, respectively, using a spectrophotometer (Genway 6305, England). Using calibration curves created using various standard values, the absorbance from each sample extract was translated to the corresponding vitamin concentrations.

2.3.4 Mineral composition determination

 According to [3], the calcium, phosphorus, magnesium, iron, zinc, and selenium levels were measured using an Atomic Absorption Spectrometer (AAS) (model 210-VPG). The AAS was calibrated using working standards made from standard solutions that are sold commercially. The findings were reported in mg/100 g of material.

2.3.5 Sensory Evaluation

Sensory evaluation of the composite flour (wheat-germinated brown rice) pasta was conducted using 14 semi-trained panelists. The panelists assessed the samples based on color, texture, taste, aroma, and overall acceptability using a 9-point hedonic score system, where 9 represented “like extremely” and 1 represented “disliked extremely”. Each pasta sample (100 g serving) were presented to the panelists alongside 250 ml of distilled water for palate cleansing between evaluations. Control and wheat-GBR composite flour pastas were served without sauce toachieved the desired parameters and eliminate potential bias.

2.4 Statistical Analysis

All experiments were carried out in replicates and data obtained were subjected to Analysis of Variance (ANOVA). Significant differences among sample means were determined at a 5% probability level (p<0>

3. Results and Discussion

3.1. Bioactive components of wheat-GBR Composite flour pasta samples

The bioactive composition of the wheat-germinated brown rice flour composite pasta revealed significant variations in total phenolic content (TPC), total flavonoid content (TFC) and gamma-aminobutyric acid (GABA) as shown in Table 2. TPC ranged from 254.58 to 338.50 mg/GAE/100 g dry weight, TFC ranged from 233.56 to 275.46 mg/QE/100 g dry weight while GABA ranged from 2.38 to 4.27 mg/100 g dry weight. 

The study recorded a significant increase (p<0>

3.2. Proximate Composition of wheat-GBR Composite flour pasta samples

The results for proximate composition as shown in Table 3 revealed significant increases (p<0>

SampleTPC (mg/GAE/100g)TFC (mg/QE/100g)GABA (mg/100g)
Sample 1254.58f±0.017233.56f±0.0312.73e±0.012
Sample 2259.39e±0.031238.27e±0.0302.38f±0.015
Sample 3308.44d±0.017245.04d±0.0353.53c±0.015
Sample 4312.33c±0.030250.03c±0.0173.12d±0.012
Sample 5325.52b±0.030259.61b±0.0174.27a±0.010
Sample 6338.50a±0.030275.46a±0.0253.96b±0.006

Values are means ± standard deviation of triplicate samples.

Mean values bearing different superscripts in the same column differs significantly p<0>

Sample 1= 70W:30GBR (12 h); Sample 2= 50W:50GBR (12 h); Sample 3= 70W:30GBR (24 h)

Sample 4= 50W:50GBR (24 h); Sample 5= 70W:30GBR (36 h); Sample 6= 50W:50GBR (36 h)

Wheat flour (W); Germinated brown rice flour (GBR); 12, 24 and 36 h are germination durations

SampleMoisture (%)Ash (%)Fat (%)Protein (%)Dietary Fiber (%)CHO (%)
Sample 14.23d±0.0361.87a±0.0203.30a±0.01512.42c±0.0207.37c±0.02070.81d±0.060
Sample 24.06e±0.0311.74c±0.0173.03b±0.02511.26d±0.0356.84d±0.01473.07a±0.061
Sample 35.24c±0.0311.80b±0.0123.03b±0.02313.49a±0.0258.77a±0.01267.67f±0.035
Sample 45.28c±0.0251.59d±0.0122.66c±0.03112.36c±0.0258.20b±0.02569.91e±0.061
Sample 55.54b±0.0461.39e±0.0252.34d±0.01712.67b±0.0315.97e±0.02072.09b±0.030
Sample 65.86a±0.0311.26f±0.0172.21e±0.02513.51a±0.0235.65f±0.02571.51c±0.010

                                                                  Table 3.Proximate Composition of Wheat-GBR Composite Flour Pasta

Values are means ± standard deviation of triplicate samples.

Mean values bearing different superscripts in the same column differs significantly p<0>

Sample 1= 70W:30GBR (12 h); Sample 2= 50W:50GBR (12 h); Sample 3= 70W:30GBR (24 h)

Sample 4= 50W:50GBR (24 h); Sample 5= 70W:30GBR (36 h); Sample 6= 50W:50GBR (36 h)

Wheat flour (W); Germinated brown rice flour (GBR); 12, 24 and 36 h are germination durations

3.3. Vitamin Content

The vitamin contents of the pasta samples are presented in Table 4.

Vitamin B1 ranged from 0.52 to 0.84 mg/100 g, showing a significant increase (p<0>

The data indicates that the concentrations of vitamins B1, B2, B3 and B6 in sample 5 were significantly higher (p<0>

3.4. Mineral Content

The mineral content of the pasta samples as presented in Table 5 increased significantly (p<0>

SampleB1B2B3B6B9E
Sample 10.57d±0.0250.35cd±0.0175.65e±0.0350.85c±0.0170.99f±0.0121.70e±0.035
Sample 20.52d±0.0250.30d±0.0105.29f±0.0300.77d±0.0301.07e±0.0301.94c±0.025
Sample 30.71bc±0.0300.39c±0.0176.33c±0.0170.96b±0.0262.82d±0.0201.83d±0.017
Sample 40.67c±0.0120.35cd±0.0356.21d±0.0301.02b±0.0122.93c±0.0352.04b±0.035
Sample 50.84a±0.0120.56a±0.0318.02a±0.0311.28a±0.0203.03b±0.0251.95c±0.017
Sample 60.73b±0.0200.48b±0.0237.13b±0.0301.23a±0.0233.14a±0.0312.16a±0.035

                                                                                Table 4: Vitamin Content (mg/100 g) of Wheat-GBR Composite Flour Pasta

Values are means ± standard deviation of triplicate samples.

Mean values bearing different superscripts in the same column differs significantly p<0>

Sample 1= 70W:30GBR (12 h); Sample 2= 50W:50GBR (12 h); Sample 3= 70W:30GBR (24 h)

Sample 4= 50W:50GBR (24 h); Sample 5= 70W:30GBR (36 h); Sample 6= 50W:50GBR (36 h)

Wheat flour (W); Germinated brown rice flour (GBR); 12, 24 and 36 h are germination durations.

SampleCa (mg/100g)Fe (mg/100g)Zn (mg/100g)Mg (mg/100g)P (mg/100g)Se (mg/100g)
Sample 126.48e±0.0173.22e±0.0171.93e±0.02029.27e±0.02522.27e±0.0317.27c±0.035
Sample 225.67f±0.0353.07f±0.0301.85f±0.03127.62f±0.03122.11f±0.0256.66d±0.017
Sample 333.53d±0.0253.74c±0.0252.26c±0.02542.31c±0.03044.28d±0.0369.17a±0.031
Sample 434.21c±0.0403.58d±0.0202.02d±0.01741.53d±0.03649.14c±0.0407.98b±0.017
Sample 538.74b±0.0174.25a±0.0122.60a±0.03653.99a±0.01263.19b±0.0305.41e±0.031
Sample 639.65a±0.0234.15b±0.0462.42b±0.01750.02b±0.01770.15a±0.0234.03f±0.035

                                                                               Table 5: Mineral Content of Wheat-GBR Composite Flour Pasta

Values are means ± standard deviation of triplicate samples.

Mean values bearing different superscripts in the same column differs significantly p<0>

Sample 1= 70W:30GBR (12 h); Sample 2= 50W:50GBR (12 h); Sample 3= 70W:30GBR (24 h)

Sample 4= 50W:50GBR (24 h); Sample 5= 70W:30GBR (36 h); Sample 6= 50W:50GBR (36 h)

Wheat flour (W); Germinated brown rice flour (GBR); 12, 24 and 36 h are germination durations

3.5. Sensory Evaluations

The results for the sensory evaluation of the formulated pasta as presented in Table 6 revealed significant increases (p<0>

The reduction in colour scores for wheat-GBR pasta could be due to the darker pigments and enzymatic browning reactions that occurred during germination. Similarly, the lower aroma and taste scores may be attributed to the characteristic nutty flavour compounds during germination. Texture scores were also reduced likely due to reduced gluten strength with partial replacement of wheat flour by GBR flour. [30] stated that texture of a product is one of the factors that determine acceptability of a product and aligns with earlier reports that incorporation of germinated cereals into wheat-based products often results in darker colour, stronger aroma and textural changes which may reduce consumer preference [12]. These findings suggest that germinated brown rice flour can be incorporated up to 50% in wheat pasta formulations without substantially diminishing sensory quality (overall acceptability approximately 5 - 6) supporting its potential use in functional and nutritionally improved pasta products that satisfy consumer preferences. 

SampleColourTextureAromaTasteOverall Acceptability
Sample 15.64ab±2.2054.50b±2.7946.07ab±2.3365.29a±2.2345.21ab±2.577
Sample 25.36ab±2.3734.07b±2.6154.29b±2.4945.00a±2.4184.86b±2.349
Sample 35.14b±2.3495.14ab±2.7975.57ab±2.8485.64a±2.9255.30ab±2.977
Sample 45.64ab±2.4374.71ab±2.4635.14ab±2.9054.93a±2.4645.57ab±2.623
Sample 55.29ab±2.4004.71ab±2.1285.21ab±2.3495.14a±2.3495.29ab±2.614
Sample 65.57ab±2.5034.71ab±2.5855.86ab±2.4455.64a±2.6496.00ab±2.572
Control7.86a±1.7917.43a±2.2097.64a±2.2407.64a±1.8237.79a±1.762
Control7.86a±1.7917.43a±2.2097.64a±2.2407.64a±1.8237.79a±1.762

                                                                            Table 6: Sensory Properties of Wheat-GBR Composite Flour Pasta

Values are means ± standard deviation of 14 responses.

Mean values bearing different superscripts in the same column differs significantly p<0>

Sample 1= 70W:30GBR (12 h); Sample 2= 50W:50GBR (12 h); Sample 3= 70W:30GBR (24 h)

Sample 4= 50W:50GBR (24 h); Sample 5= 70W:30GBR (36 h); Sample 6= 50W:50GBR (36 h)

Control= 100W

Wheat flour (W); Germinated brown rice flour (GBR); 12, 24 and 36 h are germination durations

4. Conclusion

This study demonstrates that incorporating germinated brown rice (GBR) flour into wheat-based pasta significantly enhanced its bioactive properties, proximate composition, vitamin and mineral content without while maintaining sensory acceptability. With increasing germination duration, particularly at 36 h germination, there was a notable improvement in protein, dietary fiber and ash content, indicating better nutrirional quality. Likewise, carbohydrate levels decreased slightly due to enzymatic activity during germination. The formulated pasta also has the potential of longer shelf-life due to its reduced moisture content which could favour packaging and transportation.  Vitamin analysis revealed increased levels of B-complex vitamins (B1, B2, B3, B6 and B9) and vitamin E with longer germination durations. These vitamins play crucial roles in energy metabolism and antioxidant defense. Similarly, essential minerals such as calcium, iron, zinc, magnesium, phosphorus and selenium increased significantly which improved bioavailability., The study also highlighted a significant increase in bioactive compounds, specifically Total Phenolic Content, Total Flavonoid Content and Gamma-Amino Butyric Acid with longer germination durations and higher GBR inclusion. These bioactive compounds are known for their potent antioxidant and neuroprotective properties, therefore positioning the composite pasta as a potential functional food with health-promoting benefits. Nutritional quality improved while sensory acceptability decreased compared to the control (100% wheat) pasta, though some formulations remained acceptable.  Therefore, this study presents a sustainable and nutrition conscious approach of pasta production using germinated brown rice, contributing to food security, health promotion and widespread adoption, particularly in regions facing nutritional challenges and also reduce dependence on imported wheat.

5. Recommendations

Product Development: Food industries should consider adopting germinated brown rice in pasta formulations to enhance nutritional quality. A 50W:50GBR (36 h) substitution level is recommended to maintain desirable sensory attributes while significantly improving the nutritional (dietary fiber, vitamins, minerals) and bioactive (TPC, TFC and GABA) profile. 

Consumer Sensitizations: Awareness campaigns can promote the health benefits of wheat-GBR pasta, increasing consumers’ willingness to adopt such functional foods. Addition of Natural Flavor Enhancers: Incorporating natural flavoring agents such as herbs or spices or umami-rich ingredients can mask any slight off-flavors contributed by germinated brown rice and enhance the overall sensory profile.

Author Contributions

This work was designed by Ibiye, Obubelegha Fibian Amonieah (IOFA) and Eucharia Uloma Onyeka (EUO), inputs were made by Ekpeno Sunday Ukpong (ESU). Statistical analyses were done by IOFA. The first draft was written by IOFA after which EUO and ESU read through, making their inputs and final draft was written by IOFA, while the technical and handling of data were carried out by authors NN. E, and OAF. The work was funded by IOFA and EUO.

Data availability

Data will be made available on request.

Conflicts of Interest

All the authors hereby affirm that there is no conflict of interest

References

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Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

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Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

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Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

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Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

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Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

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Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

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Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

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Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

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Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

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Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub