Efficacy of Garcinia Cambogia (HCA) in Reducing Body Weight in Overweight and Obese Adults: A Scoping Review

Research Article | DOI: https://doi.org/10.31579/2637-8914/334

Efficacy of Garcinia Cambogia (HCA) in Reducing Body Weight in Overweight and Obese Adults: A Scoping Review

  • Daniel Cool *
  • William Theile

Princess Alexandra Hospital, QLD, Australia.

*Corresponding Author: Daniel Cool, Princess Alexandra Hospital, QLD, Australia.

Citation: Daniel Cool, William Theile, (2025), Efficacy of Garcinia Cambogia (HCA) in Reducing Body Weight in Overweight and Obese Adults: A Scoping Review, J. Nutrition and Food Processing, 8(9); DOI:10.31579/2637-8914/334

Copyright: © 2025, Daniel Cool. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 18 August 2025 | Accepted: 19 September 2025 | Published: 23 September 2025

Keywords: garcinia cambogia; hydroxycitric acid; hca; weight loss; body mass index; overweight; obesity

Abstract

Aim: This scoping review investigates the weight loss claims made by listed products containing Garcinia Cambogia (from which hydroxycitric acid (HCA) is thought to be the active component). Examples include Garcinia Max (AUST L 266921) and Thinco Garcinia Supreme (AUST L 213557). 

Materials and Methods: Only studies which compared Garcinia Cambogia to placebo were included and the variables of weight change and BMI change were analysed. Double-blinded RCT’s and systematic reviews of RCT’s were included in the analysis.   

Results: Of the 14 included studies, all failed to demonstrate a clinically significant decrease in weight or BMI. Thus, none of the included studies provides sufficient evidence to support the claims made by listed weight-loss products containing Garcinia Cambogia (HCA).   

Conclusion: In addition, it is clear that there is a large problem with the standardisation of herbal products in general.  Future trials, if done, need to have parameters matching those set out in the TGA evidence guidelines and the CONSORT guidelines for reporting randomised, controlled trials of herbal interventions. 

Introduction

The use of so-called “fat burner” supplements has been increasing over recent years in attempts to combat the ever-growing issue of obesity. US data from 2007 showed that among people trying to lose weight 16 percent of people reported that they used herbal supplements to attempt to aid weight loss in the past year [1]. Consumers expect that medicine available for purchase over-the-counter will have their quality, safety and efficacy assured by the Therapeutic Goods Administration (TGA). Between 1996 and 2006 over 1000 new complementary medicines were listed in Australia, with a primary indication of weight loss; however, many did not have clear evidence of efficacy [2].  The Therapeutic Goods Administration (TGA) regulates medicines as registered products (labelled AUST-R) and listed products (labelled AUST-L) [3]. Listed medicines can be purchased off the shelf from pharmacies, health shops, and supermarkets and their efficacy does not need to be assessed before approval. This contrasts with registered products, which are assessed for safety, quality, and efficacy before they go on sale. Registered products are generally prescription-type medicines [3].

The TGA Evidence Guidelines state that “medicines targeting obese populations are required to demonstrate an absolute reduction in weight loss of at least 10% over one year” or 5% in six months. Regarding weight loss in overweight individuals, the supporting evidence must demonstrate:

  • A mean overall loss of at least 5% initial body weight in the treatment group, which is at least 3% greater (for RCT) OR 5% greater (for non-RCT) than that of the placebo group. In both cases the difference must be statistically significant (p<0>
  • At least 50% of participants in the treatment group must have achieved a loss of at least 5% of initial body weight [3]; and
  • The study duration is a minimum of 6 months [3].

A common ingredient in complementary medicines marketed for weight loss is Garcinia Cambogia (TGA-approved name: Garcinia gummi-gutt), the believed active ingredient in this product being hydroxycitric acid (HCA). There are currently around 58 products containing Garcinia or HCA found on the Australian Register of Therapeutic Goods (ARTG) [4]. Products containing HCA often claim that they reduce body weight and reduce feelings of hunger [5]. in turn resulting in weight loss. However, recent systematic reviews of RCTs have demonstrated mixed results in determining the efficacy of Garcinia compared to placebo as per the above TGA guidelines and the methods of some of these studies appear questionable [6,7].

Given a systematic review was conducted recently on this topic in 2020 [6]. a scoping review was determined to be the best way to further analyse the conclusions from both RCTs and the published reviews and provide a clearer answer to the question of garcinia’s efficacy as a fat loss supplement.  We aim to assess the efficacy of Garcinia Cambogia (HCA) as a weight-loss supplement in overweight and obese adults.

Material and Methods

This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and adhered to all relevant institutional and national research ethics guidelines. Ethical approval was obtained from the appropriate institutional review board, and informed consent was obtained from all participants prior to data collection. Data confidentiality and participant anonymity were maintained throughout the study, and all research procedures complied with applicable healthcare regulations. This review was also conducted in accordance with the PRISMA 2020 guidelines for systematic reviews and meta-analyses. The study methodology, including the selection process, data extraction, and synthesis, follows the recommended standards to ensure transparency and reproducibility. A completed PRISMA 2020 checklist and a PRISMA flow diagram have been provided as supplementary materials. The PICOT fomat (Population, Intervention, Comparator, Outcome, type of study) was used as a template to determine relevant criteria. 

We included articles that evaluated adults of normal or above normal BMI and exclude articles that only examine participants that were under 18 years of age or below normal BMI. Articles using "Garcinia Cambogia" OR "Hydroxycitric acid" OR HCA as the intervention, with placebo control will be included. We will include articles with or without diet/exercise as a co-intervention in both groups but exclude articles that include concomitant use of other weight loss supplements or active ingredients in either intervention or control group.  We will include articles with objective and measurable outcomes (weight, BMI, circumference); studies with subjective results will not be included.  Only double-blinded randomised placebo-controlled studies and systematic reviews of RCTs were included in this paper. There will be no exclusion or inclusion criteria based on the date of publication, language, or time. The literature was searched for in the following databases: PubMed, Embase, CINAHL, and Cochrane Library. A forward and backward search was conducted. Grey literature, including unpublished work on Open Science Forum (OSF) and research conducted by private companies, was also searched and appropriate bodies contacted for data or clinical trial results. 

The search terms included were: ("Garcinia Cambogia"[Title/Abstract]  OR "Hydroxycitric acid"[Title/Abstract] OR HCA[Title/Abstract]  AND Weight loss[Title/Abstract] OR BMI[Title/Abstract] OR "Body Mass Index"[Title/Abstract] OR Body composition[Title/Abstract] OR Waist circumference[Title/Abstract] OR Lean body mass[Title/Abstract] OR Body fat percentage[Title/Abstract] OR Weight change[Title/Abstract] OR Weight gain[Title/Abstract] OR Fat mass[Title/Abstract] OR Antiobesity[Title/Abstract]) OR (Obese[Title/Abstract] OR Overweight[Title/Abstract] OR Increased BMI[Title/Abstract] OR Obesity[Title/Abstract]). 

All databases will be searched from inception until October 2020.  

Prior to screening, all references were placed in an EndNote database for deduplication using the Endnote function.  Title and abstracts screening was conducted by two independent reviewers (WT and DC). Full-text screening occurred in the same fashion. All screening was done on independent EndNote files using SRA-Helper [8]. Disputes were resolved using Disputatron, and online dispute resolution software [9]. Within the data trends relating to weight loss in relation to Garcinia Cambogia. Only data from RCTs and systematic reviews was observed. The independent variable is Garcinia Cambogia/hydroxycitric acid (HCA) consumption. Assumptions being that this was the only oral intervention given.  The dependent variables are weight, BMI, waist circumference, and other 

objective measurements of weight loss, such as body fat percentage. The time frame for follow-up will be a minimum of 6 months. 

There were a variety of reasons why the 559 (figure 1) records were excluded at title and abstract screening. These included issues such as, incorrect study type (ie. observational study or literature review), focus on combination therapy only, not human studies, studies looking at adverse effects of garcinia or studies were on an unrelated area of study (ie hepatocellular adenoma – included within the HCA search term).  The reasons for exclusion at full-text screening have been described in the table below. 

Reason for Exclusion at full-text screeningAmount Excluded for the given reason 
Incorrect Study Type (Ie literature review, proposal for RCT or Prospective study) 22
Co-intervention only 
Unable to obtain study 10
Full article not published 1
English translation unavailable 1
Incorrect outcomes measured 

                                                                     Table 1: Reasons for Full Text Exclusion

The Cochrane risk of bias tool was used to critically appraise all the RCTs included in the study. The AMSTAR 2 tool was used to critically appraise all systematic reviews. Results are based on studies that were deemed to be high quality.   The extracted data was then be analysed to compare the mean and standard deviation of weight change, BMI change, body fat percentage change and waste circumferences change from the beginning of the trials, as well as the effects of dose. The results of individual studies and syntheses were tabulated using structured summary tables that 

presented key study characteristics, outcome measures, and effect estimates. Data was organised to include study design, sample size, intervention details, comparator groups, and primary weight-related outcomes (e.g., weight change, BMI, body fat percentage, and waist circumference).

Results

14 studies were included for final analysis. These are summarised in Table 2, with specific intervention discussed in Table 3. 

                                                                                                                        Table 2: Included Studies

                                                                                                 Table 3: Included Studies Intervention

The determination of the quality of description of how extracts of HCA were obtained from Garcinia Cambogia was done in accordance with the proposed CONSORT checklist by Gagnier et al [10]. Confidence  intervals of 95% give the best estimate of the true effect of the reported variable in each study and will be used to judge the statistical significance of studies where possible to do so.  Systematic Reviews are listed below. Table 4, Table 6 and Table 8 summarise the information from these. 

                                                                                                        Table 4: Systematic Reviews Weight Change

                                                                                                             Table 5: RCTs Weight Change

                                                                       Table 6: Systematic Reviews BMITable 6: Systematic Reviews BMI

                                                                                                                          Table 7: RCTs BMI

                                                                                               Table 8: Systematic Reviews Risk of Bas

                                                                                                             Table 9: RCTs Risk of Bias (see appendix)

.Systematic Reviews

Golzarand et al., 2020 (6) – Systematic review of 8 RCTs (n = 530). Compared Garcinia cambogia extract (166–4667 mg/day, unknown HCA) vs placebo for 8–12 weeks. Pooled weight change: −1.34 kg (95% CI −2.62, −0.07). Reported statistically but not clinically significant (TGA guidelines). BMI change: −0.99 kg (95% CI −1.48, −0.49). Limitations include heterogeneous dosing/follow-up, unclear sourcing/extraction, no funding, high or unclear risk of bias in several included trials. The methods were clear but <10>

Maunder et al., 2020 (11) – Review of 5 RCTs (n = 285). Garcinia (300–4667 mg/day, unknown HCA) vs placebo for 8–17 weeks. Weight change: +0.04 kg (95% CI −0.33, 0.41)—statistically and clinically insignificant. Potential conflict (author active in supplement promotion). Methods reproducible.

Onakpoya et al., 2010 (7) – Review of 9 RCTs (n = 459). HCA (1000–2800 mg/day) vs placebo for 2–12 weeks. Mean weight loss: −0.88 kg (95% CI −1.75, 0)—borderline statistical, clinically negligible. Sensitivity analysis rendered results non-significant. Poor quality of included trials. No conflicts noted.

Payab et al., 2018 (12) – Review of 5 RCTs. Garcinia (1667–3000 mg/day) vs placebo for 12–16 weeks. Mean weight change: +0.13 kg (95% CI −0.09, 0.34)—statistically/clinically insignificant. Did not specify included trials, limiting reproducibility.

Randomised Controlled Trials

Hayamizu et al., 2003 (13) – RCT (n = 44). HCA 1000 mg/day + diet/exercise vs placebo, 12 weeks. Weight loss −1.45 kg (no CI or p-value)—not statistically or clinically significant. Possible author conflict (supplier/marketer).

Preuss et al., 2004 (14) – RCT (n = 60). HCA-SX 2799 mg/day + diet/walking vs placebo, 8 weeks. Weight loss −4.53 kg (95% CI −10.83, 1.77)—statistically/clinically insignificant. BMI change also insignificant. Standardised dose; extraction details lacking.

Heymsfield et al., 1998 (15) – RCT (n = 135). Garcinia 1500 mg/day + high-fiber, low-energy diet vs placebo, 12 weeks. Mean loss −3.2 kg; between-group difference NS (p = 0.14)—clinically insignificant.

Kim et al., 2011 (16) – RCT (n = 86). Garcinia 2 g/day vs placebo, 10 weeks. Weight +0.65 kg (95% CI −0.19, 1.49)—statistically/clinically insignificant. BMI +0.24 (95% CI 0.02–0.45)—statistically significant but clinically trivial.

Kovacs et al., 2001 (17) – RCT (n = 11). HCA 500 mg/day vs placebo, 2 weeks. Weight −1.5 kg (95% CI −2.48, −0.52)—statistically significant but clinically insignificant. Funded by Novartis (not an HCA distributor).

Lu et al., 2012 (18) – RCT (n = 114). Garcinia 2800 mg/day vs placebo, 8 weeks. Weight −0.2 kg (95% CI −4.9, 4.5)—not significant; BMI unchanged.

Mattes et al., 2000 (19) – RCT (n = 89). Garcinia 1.2 g/day + low-calorie diet vs placebo, 12 weeks. Weight −3.7 kg ± 3.1 vs −2.4 ± 2.9 (p < 0 xss=removed>

Roongpisuthipong et al., 2007 (20) – RCT (n = 50). HCA 3.45 g/day + low-calorie diet vs placebo, 8 weeks. Weight +2.8 kg (95% CI 2.6–2.99)—statistically significant weight gain, not clinically relevant for weight loss.

Vasques et al., 2013 (21) – RCT (n = 43). Garcinia 2.4 g/day + low-calorie diet vs placebo, 60 days. BMI +0.17—no significant changes in anthropometric measures. Obese-only cohort limits generalisability.

Discussion

The TGA Evidence Guidelines for registered products states that “medicines targeting obese populations are required to demonstrate an absolute reduction in weight loss of at least 10% over one year” or 5% in six months. 

Regarding weight loss in mildly overweight individuals, the intended target population for listed medicines, the supporting evidence must demonstrate:

  • A mean overall loss of at least 5% initial body weight in the treatment group, which is at least 3% greater (for RCT) OR 5% greater (for non-RCT) than that of the placebo group. In both cases the difference must be statistically significant (p<0>
  • At least 50% of participants in the treatment group must have achieved a loss of at least 5% of initial body weight; and
  • The study duration is a minimum of 6 months. [22].

In addition to this, it is stated in the TGA guidelines that a loss of 1 BMI unit across populations equates to clinical significance as per Rose and Day [23]. Due to the parameter of a 6-month minimum duration, none of the included studies meets the TGA’s weight loss criteria (despite some results being statistically significant).  Other parameters, such as body fat percentage and waist circumference have been analysed but will not be discussed as, in the absence of BMI and weight change, they are not regarded as clinically significant by the TGA.  In addition to this, none of the included studies outlined how they extracted HCA (the active compound in Garcinia Cambogia) from the plant or provided stability data as outlined in the CONSORT criteria. (10) This means that the participants’ doses both within studies and between studies may be different and thus comparison is fraught. This affects both the validity and reproducibility of all studies included and explains why the results of the systematic reviews have a large variability. Preuss et. Al did use a standardised commercial formulation of HCA ensuring dose consistency within the study however the exact methods of extraction were still not outlined. 

Of the studies, whilst the majority were statistically insignificant, all studies were clinically insignificant. Statistical significance is ideally assessed using 95% confidence intervals. Several studies used P values in the absence of confidence intervals which are inferior as they do not give the best estimate of the true effect. [24]. However, neither method is perfect nor can give a 100% impression of the true effect. One study (Vasques) had neither P values, confidence intervals or standard deviations and thus statistical significance was unable to be assessed. Studies showing statistically significant weight loss were Heymsfield, Kovacs, Mattes and Onakpoya. All these studies were clinically insignificant as per the TGA guidelines. Also of note is the fact that the Preuss study was conducted on an entirely Indian population. The question of whether this is a comparable population to that of Australia should be raised. The TGA evidence guidelines state that “the meaningfulness of the observed effect to the general Australian population should also be assessed. (4)” The results of study performed on subjects on a sub-continental diet and lifestyle may not be able to be similarly replicated on an Australian population.  Four studies (Maunder, Roongpisithipong, Vasques and Payab) showed a gain in weight despite garcinia supplementation. It is clear from these results that Garcinia Cambogia/ HCA supplementation is not effective in helping weight loss. Products such as Garcinia Max (AUST L 266921) and Thinco Garcinia Supreme (AUST L 213557) are two of many Garcinia Cambogia containing products listed by AUST-L that claim to reduce body weight. The claims made include promotion of weight loss and maintenance of a healthy weight, both of which have been now shown to be false claims. Both are listed on the ARTG as AUST-L products. AUST-L products are listed over the counter medications and unlike AUST-R prescription medications, without evaluation by the TGA prior to marketing to see if they are efficacious. The TGA does undertake limited post-marketing surveillance of listed products and has consistently found a high level of regulatory non-compliance over the last 5 years [25]. Despite this the ARTG should still have investigated the product’s efficacy and monitored their advertising for false claims such as these. These disingenuous claims to the public have no evidence to support them and should be removed from retailers and the ARTG. 

Conclusion

This scoping review found no clinically meaningful evidence that Garcinia Cambogia or its active compound hydroxycitric acid (HCA) reduces body weight or BMI in overweight or obese adults. Across 14 high-quality studies, any statistically significant differences were small, inconsistent, and well below the Therapeutic Goods Administration (TGA) thresholds for clinical relevance. None of the trials met the TGA’s minimum duration or weight-loss criteria, and most lacked adequate standardisation of HCA extraction or stability data, undermining reproducibility. These findings indicate that the weight-loss claims made by listed Garcinia-containing products, such as Garcinia Max and Thinc Garcinia Supreme, are unsupported by robust evidence. The inconsistency and methodological shortcomings across studies highlight the urgent need for well-designed, long-term RCTs that follow the TGA Evidence Guidelines and CONSORT recommendations for herbal interventions. Until such evidence exists, Garcinia Cambogia should not be promoted as an effective weight-loss supplement, and regulatory bodies should ensure that marketing claims for listed products accurately reflect the current evidence base.

Author Contributions

Daniel Cool and William Theile contributed substantially to the conception and design of the study, as well as the acquisition, analysis, and interpretation of data. Daniel Cool drafted the initial manuscript. William Theile critically revised the manuscript for important intellectual content. Both authors approved the final version of the manuscript to be published and agree to be accountable for all aspects of the work, ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

References

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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe