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Research Article | DOI: https://doi.org/10.31579/2690-4861/986
1Department of Surgery No.1, Urology, Minimally Invasive Surgery, I. Horbachevsky Ternopil National Medical University, 46011 Ternopil, Ukraine.
2Enfermeras Expertas en Herides Complejas. Atenció Primària Barcelona Ciutat, Institut Català de la Salut; 08036 Barcelona, Spain.
3Outpatient Department, Hospital of Portalegre, Unidade Local de Saúde Alto Alentejo,7300-312 Portalegre, Portugal.
4Comprehensive Health Research Centre (CHRC), Universidade de Évora, 7000-671 Évora, Portugal.
5Unidade Local de Saúde, Póvoa de Varzim Vila do Conde, 4480-701 Vila do Conde, Portugal.
6Hocking Valley Community Hospital, Outpatient Wound Clinic, 43138 Ohio, USA.
7Hadassah Medical Center, 91120 Jerusalem, Israel.
8Vilnius University Hospital Santaros, 08661 Klinikos, Lithuania.
9Wladyslaw Bieganski Collegium Medicum, Jan Długosz University in Częstochowa, 42-200 Częstochowa, Poland.
10MedCu Technologies Ltd., 4672200 Herzliya, Israel.
*Corresponding Author: Gadi Borkow, MedCu Technologies Ltd., 4672200 Herzliya, Israel.
Citation: Sergii Karpeniuk, Laura B. Domínguez, Sofia M. Escobar, Rubén M. Carrillo, Eduardo G. Álvarez, et al, (2025), Effective Management of Venous Leg Ulcers by Copper Dressings – Case Series, International Journal of Clinical Case Reports and Reviews, 31(1); DOI:10.31579/2690-4861/986
Copyright: © 2025, Gadi Borkow. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 15 October 2025 | Accepted: 29 October 2025 | Published: 31 October 2025
Keywords: case series; copper oxide; dressings; venous ulcers; wound healing; antimicrobial
Background/Objective: Venous leg ulcers (VLUs) remain a therapeutic challenge, particularly in patients with multiple comorbidities and poor response to standard care. This case series evaluated the use of copper oxide–impregnated wound dressings (Copper Dressings) in 25 patients with chronic, hard-to-heal VLUs.
Methods: Patients’ VLUs were treated with Copper Dressings without adjunctive antimicrobials. The patients, treated across diverse geographies by different wound care specialists, included individuals with complex profiles such as chronic venous insufficiency, lymphedema, malnutrition, diabetes, rheumatoid arthritis, and wound infections.
Results: Treatment resulted in consistent clinical improvement, including enhanced autolytic debridement, granulation tissue formation, epithelialization, and reduction of periwound edema and exudate. The mean RESVECH 2.0 score improved from 19.52±5.38 at baseline to 2.44±4.92 (p<0.001). After an average of 9.6±5.87 weeks of treatment, 20 of 25 wounds (80%) fully healed. Importantly, infections, including those with antibiotic-resistant pathogens, were controlled without systemic antibiotics.
Conclusions: These findings clearly support Copper Dressings as a safe, effective, and biologically active option for managing refractory VLUs.
Venous leg ulcers (VLUs) are a subtype of chronic wounds resulting from chronic venous insufficiency, characterized by poor blood return from the legs to the heart, which leads to pooling, increased pressure in the veins, and eventually, skin breakdown. VLUs significantly impair patients' quality of life due to pain, limited mobility, and increased risk of infection. The prevalence of VLUs varies across studies is generally reported between 1% and 3% in the adult population in developed countries [1-3]. This prevalence increases significantly in individuals over 65 years old, due to age-related changes in vascular health [3]. These ulcers account for up to 85% of lower extremity ulcers, contributing to a high burden on healthcare systems [4]. The incidence of VLUs increases with risk factors such as obesity, prolonged standing, and previous leg injuries. They are associated with a high recurrence rate and require long-term, intensive treatment [5,6]. Key clinical features include a shallow wound with irregular edges, pain, and an inflamed peri wound area with lipodermatosclerosis [7-10]. VLUs, as many other chronic wounds, may become infected [11]. Wound infections result in wound deterioration and delay wound healing. VLUs also often develop biofilms [12,13]. It has been demonstrated that less than 40% reduction in the size of a VLU (as well as diabetic foot ulcers) during first 4 weeks of wound management indicates that the wound is refractory to the ongoing treatment [14-16]. An estimated 93% of VLUs heal within 12 months, while the remaining 7% may persist unhealed for up to five years [17]. Copper oxide impregnated wound dressings, hereafter referred to as "Copper Dressings", are in clinical use since 2019 in the USA, Europe and other countries. They are cleared for the management of acute and chronic wounds, such as diabetic ulcers, pressure sores and venous ulcers, either infected or not infected wounds, by the regulatory bodies. The Copper Dressings have potent antimicrobial efficacy, both in vitro [18] and in vivo, [19,20] including against bacteria protected by biofilm [21]. Clinical studies have demonstrated the capacity of the Copper Dressings to stimulate wound healing [22], including of hard-to-heal infected and non-infected chronic wounds that did not respond favorably to other wound management interventions [19,20,23,26]. Most of these studies were conducted with diabetic wounds and one case was reported for the successful management of a heavily infected venous ulcer by the Copper Dressings [19]. Treatment of diabetic wounds using Copper Dressings was found to be statistically significantly non-inferior to negative pressure wound therapy (NPWT) [27]. In the current case series, our aim was to examine if the Copper Dressings can also be an effective and simple management “tool” for the treatment of venous leg ulcers. To test our hypothesis, we compiled a variety of cases of stagnant, hard-to-heal VLUs that did not heal despite prior standard-of-care wound management strategies, some for even several years. We included patients with diverse underlying etiologies from different geographic locations, which were treated by different wound care experts. We report 25 cases of the successful management of VLUs by the Copper Dressings, all of which failed to heal by other wound management interventions.
Copper dressings (Figure 1) are sterile, soft, single use, wound dressings composed of an internal absorbent layer for exudating wounds containing copper-oxide particles and one external non-adherent layer impregnated with copper-oxide particles. The external layer covers the internal layer from one side, is intended to be in direct contact with the wound bed and it allows the passage of the wound exudate to the absorbent layer. The wound dressings can vertically absorb ~10 times their own weight [18]. The dressings were secured to the wound site with a secondary dressing. In highly exudating wounds, the dressings were replaced every two to three days, and as the wounds dried up, the dressings were replaced less frequently (four to six days). The dressings were used to treat the VLUs in conjunction with compression therapy.
Figure 1: Copper oxide impregnated wound dressings (Copper Dressing).
(a) The dressings are composed of one or two external non-adherent orange-colored layers and a highly absorbent layer that can absorb ~10 times its own weight [18]. The dressings are provided with or without an adhesive contour. The dressings without an adhesive contour require securing by a secondary dressing. The cuprous oxide impregnated microparticles are the white dots seen in the scanning electronic microscopy images of the orange layer (b) and the internal absorbent layer (c). Figure republished from [21] following permission by the authors.
Wound assessment included measurements, photographic documentation, and evaluation of healing progression, which was quantified using the RESVECH 2.0 score scale [28-30]. The RESVECH 2.0 scale is a validated wound assessment tool that provides a structured, quantitative description of chronic wounds, focusing on the following 6 dimensions: Wound Size / Area (evaluates surface area and reduction over time, with smaller area or progressive reduction = better score); Depth / Affected Tissue (describes how deep the wound extends, Superficial → dermis only; Medium → subcutaneous; Deep → muscle, tendon, or bone involved); Wound Edges (assess condition: attached, detached, undermined, macerated, necrotic, or rolled - healthy, attached edges score better); Type of Tissue in Wound Bed (proportion of necrotic, sloughy (fibrin), granulation, and epithelial tissue - higher presence of granulation/epithelium = better score); Exudate (amount and type - serous, purulent, sanguineous- minimal or serous exudate indicates progress, heavy or purulent exudate worsens score); and Infection/Inflammation Signs (redness, warmth, swelling, pain, odor, pus - absence of infection = best score). The scale is between 35 (worst condition) to 0 (closed and healed wound) [28-30]. For each wound, the change in RESVECH 2.0 score from the beginning to the end of the copper dressing treatment (Δ score) was calculated. Since the RESVECH 2.0 scores are ordinal numbers, the Wilcoxon signed-rank test was conducted to determine if the reduction in the RESVECH 2.0 score after treatment was statistically significant. Since the use of the Copper Dressings are cleared by the relevant regulatory bodies for clinical use and are part of the standard of care, there was no need for ethical committee approvals for this retrospective study. Informed consent was obtained from all subjects involved in the study.
25 patients, aged between 48 and 94 years, with a range of comorbidities—including chronic venous insufficiency, lymphedema, hypertension, arthritis, type 2 diabetes mellitus, chronic kidney disease, or anemia (Table 1) - were treated with copper dressings for VLUs that had persisted for 3 to 120 months. In all the patients’ countries, the use of the copper dressings is cleared to manage VLUs and any other chronic infected and non-infected chronic wounds. All patients had previously undergone unsuccessful wound management interventions, including compression therapy, enzymatic debridement, various topical dressings (primarily silver- and iodine-based), NPWT, and/or skin grafting (Table 1).
| # Patient | Main comorbidities | Age | Gender | Presence of wounds (months) | Previous dressings | Signs of infected wound | Other |
| 1 | Severe lymphedema, anemia, calf pump dysfunction, chronic venous insufficiency | 69 | F | 120 | Gauze, Iodine dressings | Yes | - |
| 2 | Chronic venous insufficiency | 65 | M | 60 | Silver and Iodine dressings | Yes | Exposed bone |
| 3 | Chronic venous insufficiency, post-thrombotic syndrome, lymphedema, dermatitis, eczema, | 48 | M | 60 | Gauze, Iodine dressings | Yes | - |
| 4 | Chronic venous insufficiency, atherosclerosis, hypertension | 70 | F | 48 | Silver, Manuka honey and Iodine dressings | Yes | Exposed Achilles tendon |
| 5 | Heart disease, hyperlipidemia, deep veins thrombosis | 82 | F | 40 | Aguacel Ag Plus Extra | Yes | - |
| 6 | Chronic venous insufficiency, arthritis, peripheral vascular disease, celiac, hypertension, hyponatremia | 72 | F | 39 | Skin graft, simple dressings | Yes | - |
| 7 | Chronic venous insufficiency, peripheral vascular disease, hypothyroidism | 68 | M | 36 | Iodine dressings, Hydroclean, Aguacel Ag | Yes | - |
| 8 | Chronic venous insufficiency, hypothyroidism, obesity, sarcopenia, depression | 53 | F | 24 | Silver dressings | Yes | - |
| 9 | Chronic venous insufficiency, psoriasis, rheumatoid arthritis | 61 | F | 13 | Silver dressings | Yes | Exposed Achilles tendon |
| 10 | Type 2 diabetes mellitus, neuropathy, hyperlipidemia, hypertensive heart disease, dermatitis | 81 | M | 8 | Aguacel Ag, Silver foam | Yes | - |
| 11 | Chronic venous insufficiency, chronic lymphedema, hypertension, osteoarthritis, hyperlipidemia, type 2 diabetes mellitus | 77 | F | 7 | NPWT, simple dressings | Yes | - |
| 12 | Chronic venous insufficiency, type 2 diabetes mellitus, bladder neoplasia, hepatic steatosis, post-thrombotic syndrome, podermatosclerosis, dermatitis | 67 | M | 6.5 | Aguacel Ag, Acticoat, Iodine dressings | Yes | - |
| 13 | Chronic venous insufficiency, type 2 diabetes mellitus, hypertensive heart disease, mixed hyperlipidemia, dermatitis, anemia | 56 | M | 6 | Aguacel Ag Plus Extra, Granuflex | Yes | - |
| 14 | Chronic venous insufficiency, chronic hepatitis C, ischemic heart disease | 65 | F | 6 | Iodine dressings, Acticoat | Yes | - |
| 15 | Chronic venous insufficiency, type 2 diabetes mellitus, hypertension, peripheral artery disease, inflammatory bowel disease, deep vein thrombosis | 94 | M | 6 | Iodine dressings, Acticoat, Aguacel Ag | Yes | Exposed bone |
| 16 | Chronic venous insufficiency, chronic osteoarticular, frailty, anemia, sarcopenia, | 86 | F | 5 | Aguacel Ag | Yes | Significant inflammation |
| 17 | Chronic venous insufficiency, type 2 diabetes mellitus, diabetic polyneuropathy, hypertension, anemia, saphenectomy, varicectomy | 79 | M | 5 | Iodine dressings | Yes | - |
| 18 | Chronic venous insufficiency, hypertension, subclinical hypothyroidism, colon neoplasia | 85 | F | 5 | Iodine dressings, Aguacel Ag | Yes | - |
| 19 | Chronic venous insufficiency, hyperlipidemia, hyperlipoproteinemia, dyslipidemia, hypertension, stasis dermatitis, cellulitis | 74 | M | 4 | Aguacel Ag | Yes | - |
| 20 | Chronic venous insufficiency, lipodermatosclerosis, dermatitis, post-thrombotic syndrome | 72 | F | 3 | Iodine dressings, Gauze | Yes | Scar avascular wound bed |
| 21 | Chronic venous insufficiency, cognitive impairment, obesity, dermatitis, lipodermatosclerosis | 56 | M | 2.5 | Iodine dressings | Yes | - |
| 22 | Chronic venous insufficiency, spinal stenosis, carpal tunnel syndrome | 61 | M | 2 | Iodine dressings, Aguacel Ag, Acticoat | Yes | - |
| 23 | Chronic venous insufficiency, carpal tunnel syndrome | 61 | F | 2 | Aguacel Ag | Yes | - |
| 24 | Chronic venous insufficiency, type 2 diabetes mellitus, hypertension | 75 | M | 1.5 | Iodine dressings, Acticoat | Yes | - |
| 25 | Chronic venous insufficiency, type 2 diabetes mellitus, chronic renal failure | 83 | M | 1.5 | Osmotic autolytic debridement | Yes | - |
Table 1: General patient characteristics at the beginning of treatment with the Copper Dressings and previous dressings used.
At the start of Copper Dressing treatment, all patients had good clear pulse palpation of the foot. A few of the patients presented with exposed bone or Achilles tendon, and all had signs of infection (Table 1). In all of the patients the Copper Dressings treatment was combined with compression therapy. Treatment with copper dressings lasted an average of 9.6 ± 5.97 weeks (Table 2), after which 20 of the 25 wounds (80%) completely healed (Figure 2). Of those 20 completely healed VLUs, 16 (80%) were completely epithelialized within the first 12 weeks of treatment, the remaining 4 clinical cases (20%) completely epithelialized within 14.6, 15, 17 and 32 weeks (clinical cases No. 3, 7, 6 and 8, respectively) of treatment. The mean RESVECH 2.0 score ± standard deviation (SD) improved significantly, from 19.52 ± 5.38 at baseline to 2.44 ± 4.92 following treatment (Table 2) (Wilcoxon signed-rank test, p<0>
| Patient | Time of Treatment (Weeks) | RESVECH 2.0 SCORE | |
| Pre-treatment | Post-treatment | ||
| 1 | 6.4 | 20 | 12 |
| 2 | 6 | 23 | 12 |
| 3 | 14.6 | 12 | 0 |
| 4 | 12 | 18 | 0 |
| 5 | 4 | 7 | 0 |
| 6 | 17 | 23 | 0 |
| 7 | 15 | 21 | 0 |
| 8 | 32 | 28 | 0 |
| 9 | 8.6 | 26 | 14 |
| 10 | 4 | 13 | 0 |
| 11 | 6 | 21 | 13 |
| 12 | 10 | 24 | 0 |
| 13 | 12 | 12 | 0 |
| 14 | 8 | 19 | 0 |
| 15 | 12 | 28 | 0 |
| 16 | 6.4 | 24 | 10 |
| 17 | 9 | 20 | 0 |
| 18 | 10 | 26 | 0 |
| 19 | 12 | 14 | 0 |
| 20 | 6.8 | 12 | 0 |
| 21 | 4 | 23 | 0 |
| 22 | 5 | 21 | 0 |
| 23 | 5 | 18 | 0 |
| 24 | 4 | 18 | 0 |
| 25 | 10 | 17 | 0 |
| Mean ± SD | 9.6 ± 5.87 | 19.52 ± 5.38 | 2.44 ± 4.92 |
Table 2: Copper Dressings Treatment.
In the present study, we report multiple cases of stagnant, hard-to-heal VLUs in patients with diverse underlying etiologies that responded favorably to treatment with Copper Dressings. Previous studies have demonstrated the capacity of Copper Dressings to stimulate wound healing through the continuum of care [19,20,22,24-26,31]; however, nearly all of those investigations focused on diabetic wounds. To date, only a single case reported the successful use of Copper Dressings in treating a heavily infected venous ulcer [19].
The cases presented here involve VLUs that did not heal despite prior standard-of-care wound management strategies—including compression therapy, NPWT and various dressing types (including antimicrobial dressings) - some for even several years. The patients studied represent a wide array of different chronic comorbidities. Remarkably, upon initiating treatment with Copper Dressings, all wounds demonstrated rapid and notable improvement in wound bed quality. This included wounds that did not respond well to antimicrobial dressings (e.g. silver containing dressings), similarly to a previous publication showing enhanced wound healing by copper dressings of wounds that responded poorly to silver dressings [23].
These improvements included enhanced autolytic debridement, emergence of granulation tissue, epithelialization, reduction in edema, and measurable wound size reduction. Importantly, no maceration of the wound margins was observed. 80 percent of the wounds closed within 12 weeks of treatment, in contrast to 93% of VLUs that heal in 12 months [17].
This case series encompasses patients from eight different countries and nine distinct wound clinics or hospitals, managed by various wound care specialists. These findings strongly suggest that the therapeutic efficacy of Copper Dressings in managing VLUs is consistent across diverse clinical settings and independent of individual practitioners’ expertise.
The copper oxide microparticles impregnated in the Copper Dressings serve as a reservoir of copper ions that are continuously liberated to the wound bed at ppm levels [19-20]. These copper ions kill pathogens present in the wound [18], primarily by plasma membrane permeabilization, membrane lipid peroxidation, and inhibition of microbial proteins assembly and activity [32]. The several parallel non-specific multisite copper antimicrobial kill mechanisms make the development of resistant microorganisms to copper extremely difficult [33]. The copper ions can also kill bacteria protected by biofilm [21].
It has been demonstrated that applying copper dressings to non-infected wounds in genetically engineered diabetic mice stimulates the secretion of key wound-healing factors through upregulation of the oxygen-sensing protein hypoxia-inducible factor-1 (HIF-1) [34]. Under hypoxic conditions, HIF-1 activates transcription of genes that promote angiogenesis, fibroblast proliferation, and keratinocyte migration, thereby accelerating tissue repair [35]. In chronic wounds such as diabetic ulcers, however, HIF-1 activity is impaired and fails to respond adequately to hypoxia [36]. Notably, copper ions not only provide broad-spectrum antimicrobial protection [37], but also directly enhance wound-healing processes by upregulating HIF-1 [34]. Today, the essential role of copper across all stages of wound healing is well established [38]. Copper ions also stimulate the secretion of vascular endothelial growth factor (VEGF), collagens and elastin by the dermal fibroblasts, promoting angiogenesis and extracellular matrix (ECM) formation during the proliferation and remodeling phases [39]. Copper is essential for the activity of Lysyl oxidase (LOX) for the ECM stabilization during the proliferation phase [39-43]. Copper is a cofactor of matrix metalloproteinases (MMPs) [44], superoxide dismutase [39] and tyrosinase [45], enzymes involved in debridement and skin remodeling, protection from oxidative stress, and for melanin production and skin pigmentation, respectively. It is thus contemplated that the stimulation of some or all of the above-mentioned factors by copper results in the stimulation of wound healing processes even in stagnated chronic wounds, including VLUs. By contrast, silver ions have been shown to downregulate HIF-1 [46], which may help explain growing evidence that silver dressings can impede wound-healing processes [47-49].
One of the bases of VLU management is compression therapy [50]. In the present case series, the Copper Dressings were used in combination with compression therapy. The level of compression (from light to strong) and the type of compression (stockings, single and multi-layer compression bandaging) depend on the level of edema, patient’s mobility (resting and walking pressure), configuration of the lower extremity, patient’s tolerance to the type and level of compression [51]. Based on our experience, Copper Dressings are suitable for use under various types of compression therapy. Due to its soft material components and sizing it can be easily applied and configured around the circumference of the lower leg under compression therapy; in consequence of its absorbent properties and minimal height, it prevents horizontal exudate leakage (maceration) and skin damage over the boarder of the dressing under compression therapy; and can be easily removed when changing the dressing.
The study is a retrospective, non-randomized case series, which inherently lacks a control group or comparator treatment arm. The study presents only a relatively small number of patients, which limits statistical power. Future studies should directly compare copper dressings against standard of care or other interventions and control for potential confounders, such as compression regimen differences, mobility and dressing change frequency across patients.
This case series provides clear evidence for the beneficial role of copper oxide–impregnated dressings in the healing of hard-to-heal venous leg ulcers. The findings align with previously established data highlighting copper’s critical involvement in key physiological wound healing processes, including angiogenesis, extracellular matrix remodeling, and antimicrobial protection. The consistent clinical improvements observed across a diverse patient population further support the use of Copper Dressings as an effective management strategy for venous leg ulcers - complementing earlier studies that demonstrated their efficacy in the treatment of diabetic wounds. These results underscore the potential of Copper Dressings to serve as a versatile and impactful tool in hard-to-heal wound care.
The following abbreviations are used in this manuscript:
NPWT Negative Pressure Wound Therapy
VLU Venous leg ulcers
CT Compression Therapy
ECM Extracellular matrix
HIF-1 Hypoxia-inducible factor-1
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
