AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/CCOR-2021/019
* Necmettin Erbakan University, GETAT CENTER, Konya, Turkey.
*Corresponding Author: Hayriye Alp, Necmettin Erbakan University, GETAT CENTER, Konya, Turkey.
Citation: Hayriye Alp (2021) Ozone Therapy and Acupuncture Application in the Treatment of Neuropathy Due to Chemotherapeutics used in Cancer Treatment. J. Clinical Cancer and Oncology Research. 1(4) DOI: 10.31579/CCOR-2021/019
Copyright: ©2021, Hayriye Alp, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 30 September 2021 | Accepted: 10 October 2021 | Published: 26 October 2021
Keywords: neuropathy; acupuncture; ozone therapy
Peripheral nervous system, vascular barrier and lymph It is susceptible to accumulation of neurotoxin due to lack of drainage with chemotherapeutic exposure long axons and myelinated fibers, decreased sensory nerve conduction velocity and intraepidermal nerve fiber loss. Due to the use of chemotherapy drugs One of the important side effects developing is peripheral neuropathy. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting disorder resulting from the administration of neurotoxic chemotherapeutic agents. In this study, we tried to investigate the effectiveness of acupuncture and ozone therapy on neuropathy.
Method: Patients who applied to Getat Polk, received cancer chemotherapy and had neuropathy complaints were included. Those who are allergic to broad bean, citrus, pregnant and antiaggregant users were excluded. In addition to 10 sessions of body and ear acupuncture, bagging ozone therapy was taken. DU-20,21, H-9,LU-7,P-6,GB-34,ST-36,KID-3-6,Shen-men,zero, Hand and foot points were pricked with disposable acupuncture needles(13x20mm Huolong). Hands and feet were placed in an ozone therapy resistant bag, and sessions were held for 20 minutes, starting from 20 gamma to 50 gamma(µg/ml).
Peripheral nervous system, vascular barrier and lymph It is susceptible to accumulation of neurotoxin due to lack of drainage. with chemotherapeutic exposure long axons and myelinated fibers, decreased sensory nerve conduction velocity and intraepidermal nerve fiber loss.Peripheral nerve degeneration or progressive intraepidermal nerve fiber loss is the main neuropathology of CIPN.
Due to the use of chemotherapy drugs one of the important side effects developing is peripheral neuropathy. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting disorder resulting from the administration of neurotoxic chemotherapeutic agents is a side effect (Argyroui 2012, Baron 2006). Treatment with platinum analogues, vinca alkaloids, taxanes, ifosfamide and methotrexate it is stated that CIPN is more common in patients with CIPN is frequently seen in 30-40% of patients and its degree varies from patient to patient. Causes a decrease in quality of life (Bhandari 2016, Beijers 2012).In chemotherapy-induced neuropathy, both motor and Sensory fibers may also be involved. Sensory neuropathy it usually causes complaints of “sock and glove” sensation in the extremities of the patient [2].
Symptoms of CIPN include paresthesia and dysesthesia in peripheral extremities, numbness, ataxia, tingling, burning, decreased sense of touch, deep tendon reflex decrease and movement and sometimes pain [1].
In KIPN, cold Losses of A8 (specific cooling) and C fibers (temperature specific) from nociceptors are also observed, causing allodynia. In general, the structural degree of damage, type of anti-cancer drugs and dosage varies depending on the regimen [6].
In this study, we tried to investigate the effectiveness of acupuncture and ozone therapy on neuropathy.
Patients who applied to Getat Polk, received cancer chemotherapy and had neuropathy complaints were included. Those who are allergic to broad bean, citrus, pregnant and antiaggregant users were excluded.
Case 1
A 15-year-old female patient, 165 cm, 64 kg, presented with the complaint of numbness and tingling in the hands and feet, and balance disorder in walking. Her blood pressure was 120/80mmHg. He stated that his complaints were in the form of tingling and then spasms about 1.5 months ago after chemotherapy. In 2020, he had adenoid operations due to ovarian ca, in 2013, and trigger finger operations in 2006-2006. He was using neurontin 300mg. His VAS was 6-7.
In addition to 10 sessions of body and ear acupuncture, bagging ozone therapy was taken. DU-20,21, H-9,LU-7,P-6,GB-34,ST-36,KID-3-6,Shen-men,zero, Hand and foot points were pricked with disposable acupuncture needles(13x20mm Huolong). Hands and feet were placed in an ozone therapy resistant bag, and sessions were held for 20 minutes, starting from 20 gamma to 50 gamma(µg/ml).
In the 3rd session, the gait and balance problem decreased. At the end of the treatment, the VAS was 2.
Case 2
A 58-year-old female patient, 67kg, 160cm, applied to polk with leg pain due to previous uterine ca. blood pressure 110770mmHg,
He had a history of cesarean section in 1985, hysterectomy in 2017, and cataract operations in 2019. He also had lymphedema and stomach complaints. 10 sessions of both acupuncture and major ozone therapy were applied to the patient. The patient was relieved in the 5th session.
Case 3
A 43-year-old female patient, 90kg, 168cm, had previous breast ca operation. 10 sessions to strengthen pain and immunity major ozone therapy was applied. Starting from 10 gamma up to 50 gamma, ozone IV was applied. The patient started to relax in the 3rd session.
Case 4
16 years old female, 63kg,160cm. her history thyroid caand diabetes.glukose 128mg/dl, HbA1c 6,1%, anti tyhroid anticor 30,22u/ml.TSH 0,5Mu7l,TgAB 15U/ml.insuline 17,3Mu/l. 10 sessions to strengthen pain and immunity major ozone therapy was applied. Starting from 10 gamma up to 50 gamma, ozone IV was applied. The patient started to relax in the 3rd session.
Case 5
A 51-year-old female patient applied to polk with hip pain after surgery uterine ca. VAS 7-8. She had anemia, HBV carrier in my history, total abdomial hysterectomy in 2017 and ankylosing spondylitis for 15 years. She was using plaquinil colcicum and aspirin 100mg.
blood sugar was 103, total cholesterol 201, Na 147, F 4.91, phosphorus 3.6, calcium 9.09, magnesium 2.08, LDH 263, B12 422, TSH 0.9, CRP 7.3, Ferritin 467, hemoglobin 9.4 mg/dl .
In the treatment, besides 10 sessions of acupuncture, ferrosanol duodenal and B vitamin replacement were added. The patient was VAS 3 in the 6th session.
Case 6
A 31-year-old female patient had been operated for lung and thymoma ca 4 years ago. He applied to polk due to neuropathic pain and insulin resistance. He had a history of cerebral hemorrhage 7 years ago and 2 strokes in his history. glucose 85, Na 142, K 4.5, calcium 9.78, total cholesterol 267, d vit 22.43, GGT 59U/L
The patient received 10 sessions of acupuncture, and at the end of 8 sessions of treatment, the VAS value due to neuropathic pain decreased to 2.
Case 7
40 years old male, 176cm,77kg. VAS 6. In his history insomnia and neuropathic pain.albumin 4.3, glukose 93, hb 15mg/dl, sgot 22, sgpt 19. Acupuncture and ozone therapy made.after therapy VAS 3.Insomnıa ıs absent.
Traditional Chinese Acupuncture has a history of about 3000 years. Acupuncture is applied to the skin and subcutaneous muscle tissue with acupuncture needles such as steel, silver and gold to the acupuncture point. By inserting the acupuncture needle into the skin, the skin and subcutaneous muscle tissue are affected by all kinds of stimuli. Thus, it causes the release of endogenous opioids, which are known to have a role in pain control, by stimulating pain receptors, that is, free nerve endings. When the pain control system is activated, neurons originating from the mesencephalon, periaqueductal gray matter and periventricular region send their impulses to the raphe magnus nucleus and nucleus reticularis paragigantocellularis. From here, the impulses descend into the dorsal column of the spinal cord and the pain-inhibitory complex located in the dorsal horn of the spinal cord. Considering this metabolism on a large scale, it is thought that acupuncture has a great effect in the treatment of pain.
In humans [7]. and rats [8], it was determined that stimulation of the muscle under the acupuncture point with a low-frequency current with a force that can cause contraction produced acupuncture analgesia, while it was observed that the current with the same characteristics applied to a point without an acupuncture point did not cause analgesia. The occurrence of analgesia as a result of stimulation of the acupuncture point was related to inhibition of neural activity in the dorsal periaqueductal gray area and brainstem reticular formation, and it was observed that acupuncture analgesia lost its effect with hypophysectomy and application of betaendorphin antiserum into the third ventricle [9].
studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms. These include opioids, which desensitize peripheral nociceptors and reduce proinflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal N-methyl-D-aspartate receptor subunit GluN1 phosphorylation [10].
Chronic pain secondary to treatment in cancer survivors without tumor evidence is not unusual. Its management often requires specific approaches that are different from those applied for cancer patients with advanced disease and short life expectancy. Some studies have described clinical benefit with ozone therapy (O3T) in the management of pain and side effects secondary to cancer treatment.ın other study all cases, except one, showed clinically relevant pain improvement. Visual analog scale score with the standard treatment was 7.8 ± 2.1 before O3T, 4.3 ± 3.4 (p = 0.049) after one month, 3.3 ± 3.7 (p = 0.024) after two months, and 2.8 ± 3.8 (p = 0.020) after three months of O3T. The median value of “pain symptom” according to the U.S. National Cancer Institute Common Terminology Criteria for Adverse Events v. 5.0 showed a decrease from 3 (range: 2–3) to 1 (range: 0–3) (p = 0.046). [11].
The mechanism of action of ozone doses is explained by the hormeceutical effect. It cannot be explained by pharmacological standards. Absorption, distribution, metabolism and excretion are outside of its pharmacological principles [16]. Ozone dose and biological effects do not show a linear relationship [17].
There are many studies on the analgesic effect of ozone therapy. In a study where patients with cervical disc hernias were administered fluoroscopically intradiscal ozone-oxygen mixtures and patients were followed up for 6, patient satisfaction even after 6 months, (VAS); visual analog scale; (ODI); OswestryDisability Index scrors were decreased. Ozone therapy was mostly used in patients with lumbar disc herniation [18]. In a study conducted by Andreula et al, compared the ozone-oxygen and periganglionic steroid injections with lumbar level in patients with LDH and found the ozone-oxygen mixture applied alone to be 70.3% more successful (Andreula CF 2003).Muto et al found it more satisfactory in the long-term (12 and 18 months) follow-ups of both intradiscal and infraforaminal ozone-oxygen injections. They found that the maximum recovery was in the 6th month and that it continued in the 18th month [20]. Buric et al. Reported that LDH patients did not experience a similar pain episode after intradiscal ozone injection for 10 years [21]..
Ozone therapy and acupuncture applications can be added to the treatment in patients who are suitable for neuropathy complaints after cancer treatment and satisfactory results can be obtained.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
